AI Article Synopsis
- This study investigates how basal ferritin levels impact prognosis and survival in myelodysplastic syndrome (MDS) patients who haven't undergone transfusions.
- The research analyzed data from 62 MDS patients, revealing that those with ferritin levels ≥400ng/mL had significantly lower survival rates and a six-fold increase in mortality risk compared to those with lower levels.
- The findings suggest that, despite a standard threshold of 1000ng/mL for starting chelation therapy, an earlier intervention may be beneficial for patients with ferritin levels as low as 400ng/mL, highlighting the need for further studies.
Article Abstract
Objectives: Myelodysplastic syndrome (MDS) is a highly mortal disease in which anemia is unresponsive to treatment. In this study, the effect of basal ferritin values on prognosis and survival was investigated in MDS patients without history of transfusion.
Methods: Data were retrospectively analyzed for 62 MDS cases. The cases were divided into two groups according to ferritin values.
Results: The mean survival time was 61.1±4.8 months. During the follow-up period, 34 (54.8%) patients deceased. Median ferritin level was 358ng/mL. The serum ferritin (SF) level associated with mortality was determined as 400ng/mL (ROC area for SF was 0.731 with a cutoff value of 400; sensitivity and specificity were 70.7% and 68.2%, respectively) (P=0.002). There were 29 (46.8%) patients with serum ferritin levels of ≥400ng/mL. Patients with serum ferritin levels≥400ng/mL had low survival rates. Ferritin≥400ng/mL was associated with six times increased mortality (P=0.001).
Conclusion: Although the acceptable ferritin level at the start of chelation therapy is 1000ng/mL, the fact that 400ng/mL value is associated with survival in our study suggests that it may be useful to start chelation therapy in the early period. Further case studies on the subject are required.
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| http://dx.doi.org/10.1016/j.tracli.2019.07.005 | DOI Listing |
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