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Lorlatinib-associated weight gain and dyslipidaemia: A retrospective analysis and implications for future care.
Lung Cancer
December 2024
The Lung Unit, The Royal Marsden NHS Trust, UK; The Institute of Cancer Research, UK. Electronic address:
Objectives: The objective of our study was to benchmark the incidence and severity of lorlatinib-related weight gain and dyslipidaemia in a real-world context, to guide future therapeutic strategies to mitigate these toxicities.
Methods: We conducted a retrospective, observational analysis of patients with ALK and ROS1-positive NSCLC at a single institution in the UK who were commenced on lorlatinib from 11/2016 to 11/2022. Non-small cell lung cancer (NSCLC) patients prescribed lorlatinib were identified through institutional electronic pharmacy records.
Global surveillance of circulating microRNA for diagnostic and prognostic assessment of acute myocardial infarction based on the plasma small RNA sequencing.
Biomark Res
November 2024
Wenzhou Key Laboratory of Emergency, Critical Care, and Disaster Medicine/Central Laboratory, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou, China.
Background: Circulating microRNAs (miRNAs) are recently a rapidly increasing of interest as non-invasive biomarkers for diagnosis and prognosis of acute myocardial infarction (AMI). Previous studies revealed that several miRNAs exhibited the capacity for diagnosis and prognosis of AMI, the reasons why these circulating miRNAs are concerned as targets for investigation are quite cryptogenic, presumably due to the lack of clues provided by global surveillance at the transcriptome level, and the current data for some miRNAs are controversial and inconsistent among independent studies.
Methods: To comprehensively profiling the potential miRNAs for diagnosis and prognosis of AMI, we reported transcriptomes of circulating miRNAs in the plasma of 27 healthy controls, 64 AMI patients (37 STEMI and 27 NSTEMI) and 20 AMI patients who were subjected to reperfusion therapy.
Pericardial Fluid Accumulates microRNAs That Regulate Heart Fibrosis after Myocardial Infarction.
Int J Mol Sci
July 2024
i3S-Institute for Research and Innovation in Health, University of Porto, 4200-135 Porto, Portugal.
Article Synopsis
- Pericardial fluid (PF) may act as a source of molecular targets for repairing heart damage after a heart attack (myocardial infarction), especially focusing on microRNAs (miRs) that modulate the heart's response.
- PF was collected from patients with different types of heart attacks (NSTEMI and STEMI) and a control group, and analyzed for miR content through small RNA sequencing to understand its effects on heart cells.
- The study found that PF from STEMI patients contains a mix of pro-fibrotic and anti-fibrotic miRs, with miR-22-3p showing potential to inhibit harmful heart cell activation, making PF a promising tool for discovering new diagnostic and therapeutic targets in
Deceptive Anteroseptal ST-segment Elevation and Brugada Pattern Caused by Isolated Conus Artery Occlusion.
Arq Bras Cardiol
June 2024
Izmir Tepecik Training and Research Hospital - Department of Cardiology, Konak, İzmir - Turquia.
The conus artery (CA) supplies the right ventricular outflow tract (RVOT). ST-segment elevation in leads V1-3, which can resemble Brugada electrocardiogram (EKG) patterns, has been reported due to occlusion of the CA. A 68-year-old male was admitted to the hospital with a diagnosis of non-ST-elevation myocardial infarction.
View Article and Find Full Text PDFThe Incidence of Cardiovascular Events in Small Versus Large Ischemic Stroke; A Three-Year Cohort Study.
ARYA Atheroscler
January 2023
Isfahan Cardiovascular Research Center, Cardiovascular Research Institute; Isfahan University of Medical Sciences; Isfahan; Iran.
Introduction: Cerebral ischemia and coronary artery disease (CAD), the major leading causes of mortality and morbidity worldwide, are pathophysiologically interrelated. Cerebral ischemic events are categorized as large or small vessels disease. The current study compares the factors related to CAD events incidence following ischemic large versus small disease CVA.
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