Two cysteine residue containing merocytochalasans (cyschalasins A and B, and ) and two 17,18--aspochalasins (secochalasins A and B, and ) were isolated from the endophytic fungus . Cyschalasins A and B represent a new type of merocytochalasan featuring the fusion of an aspochalasin with a modified cysteine residue. Secochalasins A and B are the first 17,18--aspochalasins to be reported and represent a previously undescribed carbon skeleton. Plausible biosynthetic pathways of - were proposed. Compounds and were cytotoxic and active against Gram-positive bacteria.
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| http://dx.doi.org/10.1021/acs.jnatprod.9b00016 | DOI Listing |
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