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Biomedically Relevant Self-Assembled Metallacycles and Metallacages. | LitMetric

Biomedically Relevant Self-Assembled Metallacycles and Metallacages.

J Am Chem Soc

Department of Chemistry , University of Utah, 315 South 1400 East, Room 2020 , Salt Lake City , Utah 84112 , United States.

Published: September 2019

AI Article Synopsis

Article Abstract

Diverse metal-organic complexes (MOCs), shaped as rectangles, triangles, hexagons, prisms, and cages, can be formed by coordination between metal ions (Pt, Pd, Ru, Rh, Ir, Zn, Co, and Cd) and organic ligands, with potential applications as alternatives to conventional biomedical materials for therapeutic, sensing, and imaging purposes. MOCs have been investigated as anticancer drugs in the treatment of malignant tumors in lung, cervical, breast, colon, liver, prostate, ovarian, brain, stomach, bone, skin, mouth, thyroid, and other cancers. MOCs with one, two, and three cavities have also been investigated as drug carriers and prepared for the loading and release of different drugs. In addition, MOCs can target proteins by the shape effect and recognize sugars and DNA by electrostatic interactions, as well as estradiol by host-guest interactions, etc. This Perspective mainly covers achievements in the biomedical application of MOCs. We aim to identify some key trends in the reported MOC structures in relation to their biomedical activity and potential applications.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6744948PMC
http://dx.doi.org/10.1021/jacs.9b06222DOI Listing

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