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Objective: To test a novel method to select spermatozoa with high chromatin integrity.
Design: Specimens with high sperm chromatin fragmentation (SCF) were selected by density gradient selection (DGS) and microfluidic sperm sorting (MSS).
Setting: Academic medical center.
Patient(s): Ejaculates from consenting men were processed by DGS/MSS. Couples underwent ICSI cycles with spermatozoa processed by DGS/MSS. Clinical outcomes were evaluated after embryo transfer.
Intervention(s): SCF was measured by TUNEL. ICSI with spermatozoa selected by DGS and MSS was performed.
Main Outcome Measure(s): Fertilization, embryo implantation, and pregnancy outcomes were compared between DGS and MSS.
Result(s): A total of 23 men had an average SCF of 20.7 ± 10%. After DGS and MSS, the SCF was 12.5 ± 5% and 1.8 ± 1%, respectively. In couples who underwent ICSI, the average SCF was 28.8 ± 9%, which fell to 21.0 ± 9% after DGS and 1.3 ± 0.7% after MSS. Four couples underwent 11 ICSI cycles with DGS and achieved one (25%) pregnancy that resulted in pregnancy loss. In four subsequent ICSI cycles with MSS, an ongoing clinical pregnancy rate of 50% was achieved. Five additional couples underwent 12 cycles of ICSI with DGS. After preimplantation genetic testing for aneuploidy, 30.3% of the embryos were euploid. One pregnancy was achieved, resulting in pregnancy loss. With MSS, 31.5% of the embryos were euploid and 4 couples obtained a pregnancy. Finally, sixteen couples underwent 20 ICSI cycles solely with MSS at our center. Of these couples, 8 had failed 13 ICSI cycles with DGS elsewhere. These couples achieved an overall implantation of 34.5% (10/29) and a pregnancy rate of 58.8% (10/17).
Conclusion(s): Microfluidic selection yielded spermatozoa with optimal genomic integrity and improved chances of obtaining a euploid conceptus.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6823295 | PMC |
http://dx.doi.org/10.1007/s10815-019-01543-5 | DOI Listing |
Scand Cardiovasc J
December 2025
Department of Cardiovascular Surgery, Tianjin Medical University General Hospital, Tianjin, China.
Antibiotic therapy is the primary treatment for infective endocarditis (IE), yet up to 50% of patients still require surgical intervention. However, surgical intervention carries significant risks of mortality and complications for IE patients, and there remains a lack of consensus on which preoperative characteristics of infective endocarditis have a substantial impact on patient prognosis. Particularly, some IE patients develop periannular abscesses, leading to more severe complications.
View Article and Find Full Text PDFJ Stroke Cerebrovasc Dis
December 2024
Professor in Exercise and Sport Physiology, Faculty of Physical Education and Sport Sciences, University of Tabriz, Tabriz, Iran. Electronic address:
Objectives: This study aimed to examine the effects of a multicomponent rehabilitation exercise, coupled with soymilk intake post-exercise, on cognitive impairment and ischemic lesion growth among acute stroke patients.
Methods: In a four-arm, single-blind, randomized clinical trial, 120 patients with acute stroke were randomly allocated to one of the following groups: 1) the MRE + soymilk, 2) the MRE, 3) the soymilk, and 4) the control group. Each group underwent their respective intervention for a continuous duration of 20 days.
Chem Asian J
December 2024
IIT Indore: Indian Institute of Technology Indore, Deptm. of Chemistry, Khandwa Road, Simrol, 453552, Indore, INDIA.
This study presents a highly efficient and cost-effective Cu/CeO2 catalyst for the acceptorless dehydrogenative coupling (ADC) of o-aminobenzyl alcohols and secondary alcohols to synthesize quinolines. The catalyst demonstrated over 90% yield in quinoline production under mild conditions, exhibiting excellent tolerance to various functional groups. The Cu/CeO2 catalyst, synthesized via a co-precipitation method, was thoroughly characterized through various techniques like PXRD, XPS, and AC-STEM.
View Article and Find Full Text PDFJ Clin Res Pediatr Endocrinol
December 2024
Department of Pediatric Endocrinology, Hacettepe University Faculty of Medicine, Ankara, Türkiye.
Objective: Resistance to thyroid hormone beta (RTHβ) is a rare disorder characterized by a fairly heterogeneous clinical presentation due to varying degrees of tissue response to thyroid hormone. The study aimed to evaluate the clinical, laboratory features and genotype-phenotype relationship of Turkish patients with RTHβ.
Methods: Patients who underwent a THRB gene analysis between September 2019 and September 2023 were retrospectively reviewed.
Front Pediatr
December 2024
Department of Pediatrics, Yijishan Hospital, The First Affiliated Hospital of Wannan Medical College, Wuhu, Anhui, China.
Background: Recurrent abdominal pain (RAP) is one of the most common gastrointestinal disorders in children. The aim of this study was to investigate the relationship between RAP and infection in children in Wuhu, China as well as the risk factors for infection in this region.
Materials And Methods: In this cross-sectional survey, we randomly selected children aged 6-17 years who underwent health examinations at three public hospital examination centers in Wuhu city, Anhui Province, China.
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