AI Article Synopsis
- A dimethylated imidazo[1,5-]pyridinium salt is highly soluble in water and shows fluorescence, making it useful for bioimaging.
- Under UVA-LED light, this compound can harm HeLa cancer cells by damaging their mitochondria, leading to cell death.
- This property suggests its potential as a photodynamic therapy agent for treating tumors.
Article Abstract
,'-Dimethylated imidazo[1,5-]pyridinium salt having good water solubility and exhibiting fluorescence emission was found to work as not only a bioimaging agent but also a therapeutic agent under UVA-LED irradiation conditions. Because the continuous UVA-LED irradiation to HeLa cells stained by the synthesized salt resulted in the cell death due to the mitochondrial damage, the salt has a potential application as photodynamic therapy agent against tumor cells.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6693471 | PMC |
| http://dx.doi.org/10.1021/acsmedchemlett.9b00034 | DOI Listing |
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