Dinaciclib enhances natural killer cell cytotoxicity against acute myelogenous leukemia.

Blood Adv

Division of Hematology, Oncology, and Transplantation, Department of Medicine, and.

Published: August 2019

Dinaciclib enhances NK-cell activity against leukemia cells in preclinical AML models. Enhanced NK-cell activation by dinaciclib-treated AML is associated with downregulation of inhibitory NK ligand HLA-E on leukemia cells.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6712524PMC
http://dx.doi.org/10.1182/bloodadvances.2019000064DOI Listing

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