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PTMNavigator: interactive visualization of differentially regulated post-translational modifications in cellular signaling pathways.
Nat Commun
January 2025
Proteomics and Bioanalytics, School of Life Sciences, Technical University of Munich, Freising, Germany.
Post-translational modifications (PTMs) play pivotal roles in regulating cellular signaling, fine-tuning protein function, and orchestrating complex biological processes. Despite their importance, the lack of comprehensive tools for studying PTMs from a pathway-centric perspective has limited our ability to understand how PTMs modulate cellular pathways on a molecular level. Here, we present PTMNavigator, a tool integrated into the ProteomicsDB platform that offers an interactive interface for researchers to overlay experimental PTM data with pathway diagrams.
View Article and Find Full Text PDFSupporting the Individualized Use of Digital Tools in Community Mental Health: The Technology Specialist Pilot Study.
Community Ment Health J
January 2025
Geisel School of Medicine at Dartmouth, Dartmouth Institute for Health Policy & Clinical Practice, Lebanon, NH, USA.
This pilot study evaluated the feasibility of the technology specialist intervention, which assists clients in achieving mental health recovery and well-being goals via existing digital tools in a real-world community mental health setting. Thirteen adult clients with serious mental illness and their providers completed baseline, 3-, and 6-month assessments, including goal setting, self-efficacy, activation, and acceptability measures, along with weekly ecological momentary assessments. Clients selected goals and corresponding tools, used the tools steadily, and showed improvement in activation and self-efficacy.
View Article and Find Full Text PDFA Novel Point-of-Care Prediction Model for Steatotic Liver Disease: Expected Role of Mass Screening in the Global Obesity Crisis.
Gut Liver
January 2025
Department of Internal Medicine and Liver Research Institute, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea.
Background/aims: The incidence of steatotic liver disease (SLD) is increasing across all age groups as the incidence of obesity increases worldwide. The existing noninvasive prediction models for SLD require laboratory tests or imaging and perform poorly in the early diagnosis of infrequently screened populations such as young adults and individuals with healthcare disparities. We developed a machine learning-based point-of-care prediction model for SLD that is readily available to the broader population with the aim of facilitating early detection and timely intervention and ultimately reducing the burden of SLD.
View Article and Find Full Text PDFSocial Disengagement in Post-Pandemic China: A Translation, Validation and Cross-Cultural Comparison of the Pandemic Disengagement Syndrome Scale.
J Eval Clin Pract
February 2025
Department of Psychology, University of Bologna, Bologna, Italy.
Background: In contrast to abundant research on the various acute mental effects of COVID-19, the long-term influences of the pandemic are still underexplored in China owing to the paucity of assessment tools. The Pandemic Disengagement Syndrome Scale (PDSS) assesses people's social disengagement as a lasting psychological consequence in Western countries during the post-COVID-19 pandemic era. However, its generalizability across cultures is untested.
View Article and Find Full Text PDFUnveiling the enigma: a case-based review of scleromyxedema.
Rheumatol Int
January 2025
Department of Rheumatology, Medical University of Lodz, Łódź, Poland.
Scleromyxedema is a rare chronic fibromucinous disorder characterized by a generalized papular and sclerodermoid eruption. Despite its clinical significance, no definitive therapeutic guidelines exist for scleromyxedema, making management challenging. Herein, we present a case of a 76-year-old female patient referred for evaluation of systemic sclerosis, presenting with distinctive cutaneous manifestations and neurological symptoms.
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