Hypertension (HTN) remains a common complication after kidney transplantation among paediatric patients. Although low birth weight (LBW) has been implicated as an important risk factor for cardiovascular diseases, its effect on transplantation patients has not yet been addressed. It is essential to determine whether children with LBW who undergo transplantation are more likely to develop post-transplantation HTN. For this study, the medical records of 96 kidney recipients were retrospectively examined. A total of 83 patients fulfilled the inclusion criteria. Overall, post-transplantation HTN was observed in 54% of the recipients. Multivariate logistic regression revealed that time from transplantation >14 months (odds ratio (OR) 3.6; 95% confidence interval (CI) 1.31-10.06; P = 0.013), current CKD (OR 2.6; 95% CI 1.01-7.20; P = 0.045), presence of LBW (OR 3.6; 95% CI 1.04-12.32; P = 0.044) and current overweight/obesity (OR 3.7; 95% CI 1.02-13.91; P = 0.047) were associated with post-transplantation HTN. In conclusion, our data provide evidence for the first time that LBW is a significant predictive factor in the development of post-transplantation HTN. This finding has important clinical implications as it serves to alert clinicians about this additional risk factor in paediatric patients undergoing kidney transplant.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1017/S2040174419000448 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Prevalence of hypertension and uncontrolled hypertension after solid organ transplantation: a 5-year follow-up of the Swiss Transplant Cohort Study.
J Hypertens
October 2024
Service of Nephrology and Hypertension.
Article Synopsis
- A study analyzed the prevalence and treatment of hypertension (HTN) in solid organ transplant recipients over five years, focusing on kidney, heart, lung, and liver transplants.
- The study found high rates of HTN, with prevalence ranging from 61.8% to 90.4% at different time points, and identified significant cases of uncontrolled HTN particularly in kidney, liver, and lung transplant recipients.
- Uncontrolled HTN poses a serious risk after transplantation, emphasizing the need for better management strategies, especially among liver and lung transplant patients who may not have pre-existing cardiovascular problems.
Factors associated with a higher need for antihypertensive medications at 12-months in postkidney transplant recipients: a retrospective cohort study.
Ann Med Surg (Lond)
June 2023
College of Medicine, Alfaisal University, Riyadh, Saudi Arabia.
Unlabelled: There are limited data on why some kidney transplant (KTx) recipients (KTRs) have 'difficult-to-control (DTC) hypertension' requiring greater than or equal to 2 antihypertensive medications while others require less antihypertensive medications post-KTx.
Methods: The authors reviewed the pre-KTx cardiovascular (CV) imaging, and the changes of CV risk factors during the first-year post-KTx. The authors divided patients according to the number of their blood pressure medications at one year into two groups: requiring less than or equal to 1 and requiring greater than or equal to 2 medications (DTC hypertension).
Thymus transplantation regulates blood pressure and alleviates hypertension-associated heart and kidney damage via transcription factors FoxN1 pathway.
Int Immunopharmacol
March 2023
Department of Cardiology, Second Affiliated Hospital of Naval Medical University, Shanghai 200003, China. Electronic address:
Previous studies have found that thymus is involved in the process of hypertension. However, whether thymus transplantation alleviates target organ damage in hypertensive mice remains unknown. The aim of this study was to evaluate the effects of thymus transplantation on blood pressure and target organ changes in mice with hypertension.
View Article and Find Full Text PDFCalcineurin inhibitors' impact on cardiovascular and renal function, a descriptive study in lung transplant recipients from the North of Spain.
Sci Rep
December 2022
Clinical Pharmacology Service, Marqués de Valdecilla University Hospital, 39008, Santander, Spain.
Patients undergoing lung transplantation (LTx) need administration of immunosuppressive therapy following the procedure to prevent graft rejection. However, these drugs are not exempt from potential risks. The development of cardiovascular risk factors and impaired renal function in the post-transplantation period are conditions that may be favoured by the use of calcineurin inhibitor (CNI) drugs which could have repercussions on the quality of life and the post-transplantation evolution.
View Article and Find Full Text PDFIs low birth weight an additional risk factor for hypertension in paediatric patients after kidney transplantation?
J Dev Orig Health Dis
February 2020
Department of Medicine, Nephrology Division, School of Medicine, Federal University of São Paulo, São Paulo, Brazil.
Hypertension (HTN) remains a common complication after kidney transplantation among paediatric patients. Although low birth weight (LBW) has been implicated as an important risk factor for cardiovascular diseases, its effect on transplantation patients has not yet been addressed. It is essential to determine whether children with LBW who undergo transplantation are more likely to develop post-transplantation HTN.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!