AI Article Synopsis
- IFN-γ release assays (IGRAs) show limited effectiveness in identifying Mycobacterium tuberculosis infections, failing to differentiate between active TB patients and potentially infected healthy contacts.
- In a study involving 20 TB patients and 20 healthy contacts from Ghana, researchers found that T-cells from TB patients exhibited significantly lower CD27 expression compared to healthy contacts, regardless of their Mtb-specific response.
- The study suggests that CD27 could serve as a reliable biomarker for diagnosing TB in cases where IGRAs yield unclear results.
Article Abstract
IFN-γ release assays (IGRAs) have suboptimal sensitivity for detection of Mycobacterium tuberculosis (Mtb) infection and cannot discriminate between tuberculosis (TB) patients and healthy -potentially Mtb infected- contacts (HCs). In a case-control study, we determined T-cell phenotypes of IGRAs in TB patients (n = 20) and HCs (n = 20) from Ghana. CD27 expression of T-cells was significantly lower in TB patients as compared to HCs independent from Mtb-specificity. CD27 expression discriminated both study groups - including TB patients with low or indeterminate IGRA results - effectively. We conclude that CD27 is a promising biomarker for diagnosis of TB patients with inconclusive IGRA results.
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| http://dx.doi.org/10.1016/j.micinf.2019.07.003 | DOI Listing |
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