AI Article Synopsis
- Acute myeloid leukemia (AML) is a complex blood cancer with low survival rates, influenced by various genetic factors.
- Animal models, including both non-mammalian and rodent systems, are crucial for studying different AML subtypes and their progression.
- This review evaluates various AML animal models, discussing their strengths and weaknesses, and highlights their importance in developing new treatment strategies.
Article Abstract
Acute myeloid leukemia (AML) is one of the most frequent, complex, and heterogeneous hematological malignancies. AML prognosis largely depends on acquired cytogenetic, epigenetic, and molecular abnormalities. Despite the improvement in understanding the biology of AML, survival rates remain quite low. Animal models offer a valuable tool to recapitulate different AML subtypes, and to assess the potential role of novel and known mutations in disease progression. This review provides a comprehensive and critical overview of select available AML animal models. These include the non-mammalian and models as well as the mammalian rodent systems, comprising rats and mice. The suitability of each animal model, its contribution to the advancement of knowledge in AML pathophysiology and treatment, as well as its advantages and limitations are discussed. Despite some limitations animal models represent a powerful approach to assess toxicity, and permit the design of new therapeutic strategies.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6722578 | PMC |
| http://dx.doi.org/10.3390/genes10080614 | DOI Listing |
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