Five New Cucurbitane-Type Triterpenoid Glycosides from the Rhizomes of with Cytotoxic Activities.

Five new cucurbitane-typetriterpenoid glycosides, named Xuedanoside F-J (-), were obtained from the rhizomes of (Xue dan), which belongs to the family of Cucurbitaceae. These new compounds were elucidated byspectroscopic analysis, including 1D, 2D NMR, and HR-ESI-MS spectra. Additionally, all the isolates were evaluated for cytotoxicity against three human cancer cell lines (Hela, MCF-7, and A-549) with the IC ranging from 2.25 to 49.44 µM in vitro with treatment 48 h and showed low cytotoxicity in human normal liver L-02 cells (IC > 50 µM). Compound showed the most significant cytotoxic activity with the IC value of 2.25, 4.72, and 5.33 µM in 48 h, respectively.