AI Article Synopsis
- Neural stem cells (NSC) are important for studying neural repair and potential therapies for neurodegenerative diseases, but they're hard to find and isolate due to their rarity and location.
- This study introduces a method to create immortalized cells that have NSC properties from mouse brain embryos.
- These immortalized NSCs can be cultured indefinitely, providing a stable resource for future research on neural development and regeneration.
Article Abstract
Background: Neural stem cells (NSC) have been extensively used as a tool to investigate the mechanisms responsible for neural repair, and they have been also considered as the source for a series of promising replacement therapies in various neurodegenerative diseases. However, their use is limited by their relative rarity and anatomical localization, and also because, the methods for isolation and characterization are usually time consuming and have some technical limitations.
Results: In this study, we describe a resource and method for obtaining immortalized cells with NSC characteristics obtained from mouse brain embryo.
Conclusions: Because these cells can be maintained indefinitely in culture, they may constitute a permanent source of NSC that can be used for research studies on neural development and regeneration.
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| http://dx.doi.org/10.1002/dvdy.103 | DOI Listing |
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