Three new bioactive diterpenoids from the roots of .

Nat Prod Res

School of Chinese Medicine, Shandong College of Traditional Chinese Medicine, Yantai, Shandong, 264199, People's Republic of China.

Published: May 2021

Phytochemical investigation of led to the isolation of two new halimane diterpenoids ( and ), a new -clerodane diterpenoid (), along with three known analogues (-). Their structures including absolute configurations were elucidated by spectroscopic analysis, single-crystal X-ray diffraction, and CD analysis. All isolates were evaluated for their inhibitory effects on the nitric oxide (NO) production induced by lipopolysaccharide (LPS) in RAW264.7 macrophage cells, and compound exhibited moderate inhibition of NO production with an IC value of 25.8 ± 0.9 M.

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http://dx.doi.org/10.1080/14786419.2019.1652290DOI Listing

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