A Ni-catalyzed halogenation of enol triflates was developed and it enables the synthesis of a broad range of alkenyl iodides, bromides, and chlorides under mild reaction conditions. The reaction utilizes inexpensive, bench-stable Ni(OAc) ⋅4 H O as a precatalyst and proceeds at room temperature in the presence of sub-stoichiometric Zn and either 1,5-cyclooctadiene or 4-(N,N-dimethylamino)pyridine.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC7179072 | PMC |
| http://dx.doi.org/10.1002/anie.201906815 | DOI Listing |
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