Background: Rapid infant weight gain (RIWG) is strongly related to childhood overweight and obesity, and prevention of RIWG is an approach to early years obesity prevention. This systematic review aimed to explore effectiveness, deliverers' and recipients' experiences of involvement, and key intervention components and processes of such prevention activities.
Methods: Key databases and websites were searched systematically for quantitative and qualitative studies covering intervention effectiveness, experiences with intervention involvement or process outcomes. After duplicate screening and quality assessment, papers were analyzed through narrative synthesis, thematic synthesis and intervention component analysis.
Results: Seven quantitative and seven qualitative studies were eligible for inclusion. Most intervention studies reported small, but significant results on infant weight gain. More significant results were measured on weight gain during the first compared with the second year of life. A weak evidence base made elaboration of the relationship between intervention effectiveness and content challenging. Home-delivered interventions may be more relevant for parents. Contextual factors, such as social norms, beliefs and professional identity should be considered during intervention development. Stakeholder involvement can be key to increase intervention acceptability and feasibility.
Conclusions: The field of RIWG prevention is new and evolving, but more research is needed before further conclusions about intervention effectiveness and intervention content can be drawn. Future interventions should take parents, health professionals and other contextual needs into account to improve chances of success. More research on long-term effects on overweight and obesity is needed.
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http://dx.doi.org/10.1093/eurpub/ckz140 | DOI Listing |
J Cell Mol Med
March 2025
Department of Cardiology, The Affiliated Hospital of Jiangnan University, Wuxi, Jiangsu, China.
Recent research has revealed a close association between obesity and various metabolic disorders, including renal metabolic diseases, but the mechanism is still unknown. This study explored the role of p16INK4a in obesity-related kidney fibrosis and evaluated its potential as a therapeutic target. Using wild-type (WT) mice and p16 KO mice, we fed both groups a high-fat diet (HFD) for 6 months.
View Article and Find Full Text PDFFront Immunol
March 2025
Fisheries College of Jimei University, Xiamen Key Laboratory for Feed Quality Testing and Safety Evaluation, Xiamen, China.
Introduction: The aim of this study is to investigate the effects of supplementing () on hybrid grouper ( ♀ × ♂), with a particular focus on its impact on growth performance, blood composition, intestinal antioxidant capacity, gut microbiota, tight junction protein (ZO-1) expression, and inflammatory gene expression. The study seeks to uncover the potential health benefits of C. butyricum supplementation for hybrid grouper.
View Article and Find Full Text PDFInt J Womens Health
March 2025
Department of Obstetrics and Gynecology, National Clinical Research Center for Obstetric & Gynecologic Diseases, State Key Laboratory of Common Mechanism Research for Major Diseases, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, 100730, People's Republic of China.
Purpose: This study aims to investigate the differences in pelvic floor dysfunction (PFD) and diastasis recti abdominis (DRA) between primiparous and second-parous females with known risk factors controlled.
Patients And Methods: 49 primiparous and 49 age-matched second-parous postpartum after spontaneous vaginal delivery were included between October and December 2023. Independent variables include weight, height, body mass index (BMI), fetal weight, gestational weight gain (GWG).
Cureus
February 2025
Pulmonology, Carolina Lung Clinic, Piedmont Medical Center, Rock Hill, USA.
This case report details a 61-year-old male patient with a history of chronic obstructive pulmonary disease (COPD) and significant smoking exposure, who presented with progressive anorexia, weight loss, nocturnal sweating, and worsening respiratory symptoms in early 2024. Imaging revealed bi-apical opacities with cavitation, and sputum cultures identified , a rare nontuberculous mycobacterium (NTM). The patient was managed with a multi-drug regimen including azithromycin, rifampin, and ethambutol, targeting symptom relief, radiographic stability, and sputum conversion.
View Article and Find Full Text PDFObjective: Maternal obesity and excessive weight gain during pregnancy predispose to adverse fetal outcomes and health issues for the offspring. Although maternal lipids play an important role in excess fetal fat accretion, previous studies found heterogeneous results regarding which lipid fraction is most involved in excessive fetal growth in maternal obesity and the role of cord lipids. The aim of this study was to evaluate lipid concentrations in maternal and cord blood in pregnant women with and without obesity and to correlate lipid profile with neonatal and placental biometric parameters.
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