We have synthesized new series of bisindole analogs (-), characterized by HNMR and HR-EI-MS and evaluated for their anti-leishmanial potential. All compounds showed outstanding inhibitory potential with IC values ranging from 0.7 ± 0.01 to 13.30 ± 0.50 µM respectively when compared with standard pentamidine with IC value of 7.20 ± 0.20 µM. All analogs showed greater potential than standard except , and when compared with standard. Structure activity relationship has been also established for all compounds. Molecular docking studies were carried out to understand the binding interaction of active molecules.
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| http://dx.doi.org/10.1186/s13065-019-0617-4 | DOI Listing |
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