Rhythmogenesis is the process that develops the capacity for rhythmic activity in a non-rhythmic system. Theoretical works suggested a wide array of possible mechanisms for rhythmogenesis ranging from the regulation of cellular properties to top-down control. Here we discuss theories of rhythmogenesis with an emphasis on spike timing-dependent plasticity. We argue that even though the specifics of different mechanisms vary greatly they all share certain key features. Namely, rhythmogenesis can be described as a flow on the phase diagram leading the system into a rhythmic region and stabilizing it on a specific manifold characterized by the desired rhythmic activity. Functionality is retained despite biological diversity by forcing the system into a specific manifold, but allowing fluctuations within that manifold.
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http://dx.doi.org/10.1016/j.conb.2019.07.005 | DOI Listing |
Front Netw Physiol
August 2024
Department of Mathematics and Statistics and Neuroscience Institute, Georgia State University, Atlanta, GA, United States.
Proc Natl Acad Sci U S A
May 2024
Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle, WA 98101.
How breathing is generated by the preBötzinger complex (preBötC) remains divided between two ideological frameworks, and a persistent sodium current (I) lies at the heart of this debate. Although I is widely expressed, the pacemaker hypothesis considers it essential because it endows a small subset of neurons with intrinsic bursting or "pacemaker" activity. In contrast, burstlet theory considers I dispensable because rhythm emerges from "preinspiratory" spiking activity driven by feed-forward network interactions.
View Article and Find Full Text PDFbioRxiv
November 2023
Center for Integrative Brain Research, Seattle Children's Research Institute, Seattle WA, USA.
How breathing is generated by the preBötzinger Complex (preBötC) remains divided between two ideological frameworks, and the persistent sodium current () lies at the heart of this debate. Although is widely expressed, the considers it essential because it endows a small subset of neurons with intrinsic bursting or "pacemaker" activity. In contrast, considers dispensable because rhythm emerges from "pre-inspiratory" spiking activity driven by feed-forward network interactions.
View Article and Find Full Text PDFNeural oscillations in the 8-12 Hz alpha band are thought to represent top-down inhibitory control and to influence temporal resolution: Individuals with faster peak frequencies segregate stimuli appearing closer in time. Recently, this theory has been challenged. Here, we investigate a special case in which alpha does not correlate with temporal resolution: when stimuli are presented amidst strong visual drive.
View Article and Find Full Text PDFCurr Opin Neurobiol
October 2019
Department of Physiology and Cell Biology, Faculty of Health Sciences, Department of Physics, Faculty of Natural Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Be'er-Sheva, Israel; The Kavli Institute for Theoretical Physics, University of California, Santa Barbara, USA. Electronic address:
Rhythmogenesis is the process that develops the capacity for rhythmic activity in a non-rhythmic system. Theoretical works suggested a wide array of possible mechanisms for rhythmogenesis ranging from the regulation of cellular properties to top-down control. Here we discuss theories of rhythmogenesis with an emphasis on spike timing-dependent plasticity.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!