Theories of rhythmogenesis.

Curr Opin Neurobiol

Department of Physiology and Cell Biology, Faculty of Health Sciences, Department of Physics, Faculty of Natural Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Be'er-Sheva, Israel; The Kavli Institute for Theoretical Physics, University of California, Santa Barbara, USA. Electronic address:

Published: October 2019

Rhythmogenesis is the process that develops the capacity for rhythmic activity in a non-rhythmic system. Theoretical works suggested a wide array of possible mechanisms for rhythmogenesis ranging from the regulation of cellular properties to top-down control. Here we discuss theories of rhythmogenesis with an emphasis on spike timing-dependent plasticity. We argue that even though the specifics of different mechanisms vary greatly they all share certain key features. Namely, rhythmogenesis can be described as a flow on the phase diagram leading the system into a rhythmic region and stabilizing it on a specific manifold characterized by the desired rhythmic activity. Functionality is retained despite biological diversity by forcing the system into a specific manifold, but allowing fluctuations within that manifold.

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http://dx.doi.org/10.1016/j.conb.2019.07.005DOI Listing

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Theories of rhythmogenesis.

Curr Opin Neurobiol

October 2019

Department of Physiology and Cell Biology, Faculty of Health Sciences, Department of Physics, Faculty of Natural Sciences, Zlotowski Center for Neuroscience, Ben-Gurion University of the Negev, Be'er-Sheva, Israel; The Kavli Institute for Theoretical Physics, University of California, Santa Barbara, USA. Electronic address:

Rhythmogenesis is the process that develops the capacity for rhythmic activity in a non-rhythmic system. Theoretical works suggested a wide array of possible mechanisms for rhythmogenesis ranging from the regulation of cellular properties to top-down control. Here we discuss theories of rhythmogenesis with an emphasis on spike timing-dependent plasticity.

View Article and Find Full Text PDF

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