AI Article Synopsis
- - The study investigated the relationship between ghrelin dynamics (hormone related to hunger) and beta cell function (insulin production) during oral glucose tolerance tests in healthy individuals under 40 years old.
- - Researchers found that specific indicators of insulin sensitivity (like Stumvoll-1 and insulinogenic index) showed significant correlations in nonobese subjects, suggesting that their beta cell function and ghrelin levels change with BMI.
- - The results indicate that higher BMI is linked to increased glucose and insulin levels, while lowering ghrelin dynamics and beta cell function could contribute to insulin resistance and glucose intolerance in obese individuals.
Article Abstract
Background: Ghrelin is involved in feeding regulation and energy metabolism and is also known to inhibit insulin secretion (β). However, few clinical studies have demonstrated the relationship between β and ghrelin dynamics. This study tested the hypothesis that, in oral glucose tolerance tests (OGTT), ghrelin dynamics are associated with β.
Methods: Subjects were 1145 healthy individuals <40 years old who tested normal on the 75-g OGTT. The following indicators and the ghrelin suppression ratio (GSR) during OGTT were calculated: insulin sensitivity (SI) [1/homoeostasis model assessment of insulin resistance, insulin sensitivity index-Matsuda and 1/fasting insulin (1/FIRI)]; and β [Stumvoll first-phase index (Stumvoll-1), Stumvoll second-phase index and insulinogenic index]. From nine combinations of SI and β, combinations that produce hyperbolic relationships were identified.
Results: Stumvoll-1 and 1/FIRI showed a hyperbolic relationship in nonobese subjects, and the product of Stumvoll-1 and 1/FIRI was used as the disposition index (DI). When analyzed by BMI quartiles, post-loading glucose and insulin levels at each time point increased from Q1 (low BMI) through Q4 (high BMI), whereas the DI, ghrelin levels at each time point, and GSR decreased from Q1 to Q4. On multivariate and bivariate analysis, GSR and DI were positive and independent, and fasting ghrelin and FIRI were negatively and independently correlated.
Conclusions: Ghrelin dynamics were associated with beta cell function in subjects with normal glucose tolerance. Glucose intolerance in obesity may be due not only to insulin resistance but also to impaired beta cell function associated with abnormalities of ghrelin dynamics.
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| http://dx.doi.org/10.1111/cen.14073 | DOI Listing |
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Article Synopsis
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- - The findings revealed that zebrafish lacking LEAP2 showed enhanced growth metrics, such as hatching rate and body size, alongside increased GH expression, indicating that LEAP2 plays a significant role in regulating growth during early developmental stages.
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