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Retrospective Analysis of Ceftriaxone 1 Gram or 2 Grams for Bacteremia.
J Pharm Pract
January 2025
Emergency Medicine, Department of Pharmacy, Long Island Jewish Valley Stream, Valley Stream, NY, USA.
Ceftriaxone is a third-generation cephalosporin commonly used for treating bacteremia caused by gram-positive organisms such as and gram-negative organisms such as Enterobacterales. The typical doses for treating bacteremia are either 1 gram or 2 grams daily. Despite its widespread use, there are limited data on the optimal treatment dose for bacteremia.
View Article and Find Full Text PDFDynamic collateral sensitivity profiles highlight opportunities and challenges for optimizing antibiotic treatments.
PLoS Biol
January 2025
Department of Biophysics, University of Michigan, Ann Arbor, Michigan, United States of America.
As failure rates for traditional antimicrobial therapies escalate, recent focus has shifted to evolution-based therapies to slow resistance. Collateral sensitivity-the increased susceptibility to one drug associated with evolved resistance to a different drug-offers a potentially exploitable evolutionary constraint, but the manner in which collateral effects emerge over time is not well understood. Here, we use laboratory evolution in the opportunistic pathogen Enterococcus faecalis to phenotypically characterize collateral profiles through evolutionary time.
View Article and Find Full Text PDFA Nationwide Evaluation of Antibiotic Consumption in Kazakhstan from 2019 to 2023.
Antibiotics (Basel)
November 2024
Graduate School of Public Policy, Nazarbayev University, Astana 010000, Kazakhstan.
Background/objectives: There has been a lack of a holistic approach to evaluating antibiotic consumption in Kazakhstan over the past few years using an internationally recognized methodology. Therefore, this study aimed to provide a nationwide evaluation of antibiotic consumption in Kazakhstan during the period 2019-2023.
Methods: Defined daily doses per 1000 inhabitants per day (DIDs) were calculated for systemic antibiotics (J01 code of the Anatomical Therapeutic Chemical Classification System (ATC)) following the methodology established by the Global Antimicrobial Resistance and Use Surveillance System (GLASS-AMC).
Combined Antibiotic and Photodynamic Therapies in : From Synergy to Antagonism.
Antibiotics (Basel)
November 2024
Biomedical Engineering, Texas A&M University, College Station, TX 77843, USA.
Antibiotics remain the most effective option for combating infections. However, the situation has shifted from ideal to concerning, as bacterial resistance to antibiotics is increasing in both prevalence and strength. : This study explores the synergistic/antagonistic potential of combining antibiotic and photodynamic therapy (PDT) against .
View Article and Find Full Text PDFEffect of tropical climates on the quality of commonly used antibiotics: the protocol for a systematic review and meta-analysis.
BMJ Open
January 2025
Clinical Research Department, KEMRI-Wellcome Trust Research Programme, Kilifi, Kenya.
Introduction: Medicine quality can be influenced by environmental factors. In low- and middle-income countries (LMICs) with tropical climates, storage facilities of medicines in healthcare settings and homes may be suboptimal. However, knowledge of the effects of temperature and other climatic and environmental factors on the quality of medicines is limited.
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