Aim: To assess antidepressant properties of remote ischemic limb pre- and post-conditioning.
Material And Methods: The study was performed with rats that were subjected to unavoidable aversive stress in the 'learned helplessness' paradigm for developing experimental depression, or were additional exposed to three brief episodes of ischemia/reperfusion of the limb before or after stressing.
Results: Remote ischemic preconditioning completely prevented depressive-like behavior and caused hyperactivation of the pituitary-adrenal hormonal axis. Ischemic post-conditioning did not completely correct post-stress hormone dysregulation and animal stress-reactivity.
Conclusion: Remote ischemic pre- and post-conditioning has a pronounced antidepressant effect and prevents the formation of the main behavioral and endocrine signs of experimental depression.
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| http://dx.doi.org/10.17116/jnevro201911906172 | DOI Listing |
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