Background: This study investigates the characteristics of a special type of cancer of unknown primary site (CUP, type 2), which is a metastasis of a definite pathological diagnosis without a detectable primary site.
Patients And Methods: Patients diagnosed between 2004 and 2014 were identified from the Surveillance Epidemiology and End Results (SEER) database. The characteristics of type 2 CUP from different sources were analyzed. For each source of type 2 CUP, tumors of the corresponding T N M stage were used as controls.
Results: A total of 8505 patients with type 2 CUP were included in this analysis. Type 2 CUP shows an increasing trend, while type 1 shows the opposite. Type 2 CUPs have significant differences with stage IV of the same pathological primary lesion. Many characteristics influenced the prognosis of type 2 CUP patients, including marital status, age, race, sex, registration time, lymph node metastasis, surgery, chemotherapy, and radiation.
Conclusion: Our study suggests that identifying the source of metastasis is the key to the selection of treatment and the determination of the prognosis for CUP.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6792521 | PMC |
| http://dx.doi.org/10.1002/cam4.2496 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
In cybersecurity, anomaly detection in tabular data is essential for ensuring information security. While traditional machine learning and deep learning methods have shown some success, they continue to face significant challenges in terms of generalization. To address these limitations, this paper presents an innovative method for tabular data anomaly detection based on large language models, called "Tabular Anomaly Detection via Guided Prompts" (TAD-GP).
View Article and Find Full Text PDFOmega-3 fatty acids: molecular weapons against chemoresistance in breast cancer.
Cell Mol Biol Lett
January 2025
Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Arcavacata Di Rende, 87036, Cosenza, Italy.
Breast cancer is the most commonly diagnosed type of cancer and the leading cause of cancer-related death in women worldwide. Highly targeted therapies have been developed for different subtypes of breast cancer, including hormone receptor (HR)-positive and human epidermal growth factor receptor 2 (HER2)-positive breast cancer. However, triple-negative breast cancer (TNBC) and metastatic breast cancer disease are primarily treated with chemotherapy, which improves disease-free and overall survival, but does not offer a curative solution for these aggressive forms of breast cancer.
View Article and Find Full Text PDFEmpagliflozin in diabetic cardiomyopathy: elucidating mechanisms, therapeutic potentials, and future directions.
Mol Biol Rep
January 2025
Department of Pharmacology, Central University of Punjab, Bathinda, Punjab, 151401, India.
Diabetic cardiomyopathy (DCM) represents a significant health burden, exacerbated by the global increase in type 2 diabetes mellitus (T2DM). This condition contributes substantially to the morbidity and mortality associated with diabetes, primarily through myocardial dysfunction independent of coronary artery disease. Current treatment strategies focus on managing symptoms rather than targeting the underlying pathophysiological mechanisms, highlighting a critical need for specific therapeutic interventions.
View Article and Find Full Text PDF[Application of personalized three-dimensional printed customized prostheses in severe Paprosky type acetabular bone defects].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
January 2025
Department of Artificial Joint Revision, Luoyang Orthopedic-Traumatological Hospital of Henan Province (Henan Provincial Orthopedic Hospital), Zhengzhou Henan, 450003, P. R. China.
Objective: To analyze the short-term effectiveness and safety of personalized three-dimensional (3D) printed customized prostheses in severe Paprosky type Ⅲ acetabular bone defects.
Methods: A retrospective analysis was conducted on 8 patients with severe Paprosky type Ⅲ acetabular bone defects and met the selection criteria between January 2023 and June 2024. There were 3 males and 5 females, with an average age of 64.
Analysis of the therapeutic effect of EarWell ear orthotics on elderly children with congenital ear deformities within 98 days.
Int J Pediatr Otorhinolaryngol
January 2025
Department of Otolaryngology, Liangxiang Hospital of Beijing, Fangshan District, 102401, China.
Objective: To observe the efficacy of EarWell ear orthotics in treating congenital ear deformities in older children (≥7 weeks) within 98 days.
Method: A retrospective study was conducted on 58 infants (69 ears) aged 7-14 weeks after birth. Divided into three groups: A (7-9 weeks old, 26 ears), B (10-12 weeks old, 23 ears), and C (13-14 weeks old, 20 ears).
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!