AI Article Synopsis
- Sitafloxacin is effective against various respiratory pathogens, showing promising results for treating infections in critically ill patients.
- Blood and bronchoalveolar lavage (BAL) samples were collected from 12 patients after taking a single oral dose of 200 mg, revealing good drug penetration into the epithelial lining fluid (ELF).
- The study found an average ELF to plasma concentration ratio of about 1.02, indicating that sitafloxacin effectively reaches the site of infection in patients with pneumonia.
Article Abstract
Sitafloxacin showed potent activity against various respiratory pathogens. Blood and bronchoalveolar lavage (BAL) fluid samples were obtained from 12 subjects after a single oral dose of sitafloxacin 200 mg. The mean ± SD (median) maximum ratio of epithelial lining fluid (ELF) to unbound plasma concentration was 1.02 ± 0.58 (1.33). The penetration ratios based on the mean and median area under the curve from 0 to 8 h (AUC) were 0.85 and 0.79 μg · h/ml, respectively. Sitafloxacin penetrates well into ELF in critically ill Thai patients with pneumonia. (This study has been registered in the Thai Clinical Trials Registry [TCTR] under registration no. TCTR20170222001.).
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6761513 | PMC |
| http://dx.doi.org/10.1128/AAC.00800-19 | DOI Listing |
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