Association between short-term exposure to fine particulate matter (PM) and mortality or morbidity varies geographically, and this variation could be due to different chemical composition affected by local sources. However, there have been only a few Asian studies possibly due to limited monitoring data. Using nationwide regulatory monitoring data of PM chemical components in South Korea, we aimed to compare the associations between daily exposure to PM components and mortality across six major cities. We obtained daily 24-h concentrations of PM and 11 PM components measured from 2013 to 2015 at single sites located in residential areas. We used death certificate data to compute the daily counts of nonaccidental, cardiovascular, and respiratory deaths. Using the generalized additive model, we estimated relative risks of daily mortality for an interquartile range increase in each pollutant concentration, while controlling for a longer-term time trend and meteorology. While elemental carbon was consistently associated with nonaccidental mortality across all cities, nickel and vanadium were strongly associated with respiratory or cardiovascular mortality in Busan and Ulsan, two large port cities. Our study shows that PM components responsible for PM-associated mortality differed across cities depending on the dominant pollution sources, such as traffic and oil combustion.
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http://dx.doi.org/10.3390/ijerph16162872 | DOI Listing |
J Integr Neurosci
December 2024
Department of Neurology, Hainan West Central Hospital, 571799 Danzhou, Hainan, China.
Background: Ischemic stroke (IS) is the leading cause of mortality worldwide. Herein, we aimed to identify novel biomarkers and explore the role of C-type lectin domain family 7 member A () in IS.
Methods: Differentially expressed genes (DEGs) were screened using the GSE106680, GSE97537, and GSE61616 datasets, and hub genes were identified through construction of protein-protein interaction networks.
Ther Adv Neurol Disord
December 2024
Huashan Rare Disease Center and Department of Neurology, Huashan Hospital, Shanghai Medical College, National Center for Neurological Disorders, Fudan University, No.12 Urumqi Middle Road, Jing 'an District, Shanghai 200040, China.
Background: Thymoma-associated myasthenia gravis (TAMG) is a subtype of myasthenia gravis (MG) that is associated with more severe symptoms and a relatively poor prognosis. Eculizumab, an inhibitor to target human C5 component of the complement cascade, is considered a treatment option for refractory generalized MG (gMG).
Objectives: To explore the safety and efficacy of eculizumab in patients with TAMG.
Ann Glob Health
December 2024
Department of Public Health, Faculty of Medicine and Health Sciences, Walter Sisulu University, South Africa.
In Zimbabwe, studies have mainly focused on child and maternal factors contributing to under‑5‑year mortality, and little has been published concerning the paternal social determinants, which are also important. The goal of this paper is to investigate the paternal social determinants of infant and childhood mortality in Zimbabwe. The study analyzed cross‑sectional secondary data from the Zimbabwe Demographic Health Survey (ZDHS) 2015 to investigate paternal determinants of infant and child mortality.
View Article and Find Full Text PDFTurk J Med Sci
December 2024
Department of Medical Biology, Faculty of Medicine, Kocaeli University, Kocaeli, Turkiye.
Background/aim: Lung cancer, a predominant contributor to cancer mortality, is characterized by diverse etiological factors, including tobacco smoking and genetic susceptibilities. Despite advancements, particularly in nonsmall-cell lung cancer (NSCLC), therapeutic options for lung squamous cell carcinoma (LUSC) are limited. Transposable elements (TEs) and their regulatory proteins, such as tigger transposable element derived (TIGD) family proteins, have been implicated in cancer development.
View Article and Find Full Text PDFEndocr Pract
December 2024
Division of Endocrinology, Diabetes, Metabolism, and Nutrition Mayo Clinic, Rochester, MN.
People with chronic kidney disease (CKD) are at increased risk of fractures in comparison to the non-CKD population and fractures are associated with high mortality and worsening quality of life. The higher risk observed in the CKD population is related to the complex interplay of CKD-mineral bone disorder (MBD) abnormalities causing changes in bone turnover (T), mineralization (M), and volume (V), along with other risk factors accumulated as glomerular filtration rate declines. The approach for evaluation of bone disease and fracture risk in CKD is different from the approach in the general population.
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