The IoT describes a development field where new approaches and trends are in constant change. In this scenario, new devices and sensors are offering higher precision in everyday life in an increasingly less invasive way. In this work, we propose the use of spatial-temporal features by means of fuzzy logic as a general descriptor for heterogeneous sensors. This fuzzy sensor representation is highly efficient and enables devices with low computing power to develop learning and evaluation tasks in activity recognition using light and efficient classifiers. To show the methodology's potential in real applications, we deploy an intelligent environment where new UWB location devices, inertial objects, wearable devices, and binary sensors are connected with each other and describe daily human activities. We then apply the proposed fuzzy logic-based methodology to obtain spatial-temporal features to fuse the data from the heterogeneous sensor devices. A case study developed in the UJAmISmart Lab of the University of Jaen (Jaen, Spain) shows the encouraging performance of the methodology when recognizing the activity of an inhabitant using efficient classifiers.
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http://dx.doi.org/10.3390/s19163512 | DOI Listing |
Braz J Microbiol
January 2025
Center of Technological Development, Biotechnology, Federal University of Pelotas, Pelotas, Rio Grande do Sul, Brazil.
Adjuvants are crucial for maintaining specific, protective, and long-lasting immunity. Here, we aimed to evaluate the antigenic and immunogenic activity of a recombinant form of the S1 domain of the Spike protein, associated with biogenic silver nanoparticles (bio-AgNP) and Alhydrogel as an alternative and conventional adjuvant, respectively, for a SARS-CoV-2 subunit vaccine. We produced and evaluated the antigenicity of the recombinant S1 (rS1) protein by testing its recognition by antibodies present in SARS-CoV-2 positive human serum.
View Article and Find Full Text PDFCurr Opin Neurol
January 2025
Department of Neurology, Sri Ramachandra Institute of Higher Education and Research, Porur, Chennai, India.
Purpose Of Review: This review explores the phenomenology, pathogenesis, and nosology of headaches associated with infections, an often-overlooked yet clinically significant symptom. With the increasing recognition of secondary headaches in infections, understanding their clinical patterns, mechanisms, and classifications is crucial for accurate diagnosis and management.
Recent Findings: Headaches in infections are ubiquitous but vary in presentation, severity, and underlying mechanisms depending on the causative pathogen.
iScience
February 2025
Jiangsu Key Laboratory of Immunity and Metabolism, Department of Pathogenic Biology and Immunology, Xuzhou Medical University, Xuzhou, Jiangsu, China.
Pattern recognition receptors (PRRs), consisting of Toll-like receptors, RIG-I-like receptors, cytosolic DNA sensors, and NOD-like receptors, sense exogenous pathogenic molecules and endogenous damage signals to maintain physiological homeostasis. Upon activation, PRRs stimulate the sensitization of nuclear factor κB, mitogen-activated protein kinase, TANK-binding kinase 1-interferon (IFN) regulatory factor, and inflammasome signaling pathways to produce inflammatory factors and IFNs to activate Janus kinase/signal transducer and activator of transcription signaling pathways, resulting in anti-infection, antitumor, and other specific immune responses. Palmitoylation is a crucial type of post-translational modification that reversibly alters the localization, stability, and biological activity of target molecules.
View Article and Find Full Text PDFCureus
December 2024
Internal Medicine, Unidade Local de Saúde do Oeste - Hospital Distrital de Caldas da Rainha, Caldas da Rainha, PRT.
Subclavian artery aneurysm is an extremely rare condition with potentially life-threatening complications, including rupture and embolization. This condition is generally the result of atherosclerosis, medial degeneration, trauma, or infection. We report the case of an 83-year-old man who developed hemoptysis due to the rupture of a saccular aneurysm at the origin of the left subclavian artery.
View Article and Find Full Text PDFFront Immunol
January 2025
Institute for Virology, University Hospital Essen, University of Duisburg-Essen, Essen, Germany.
Natural killer (NK) cells are innate immune cells that play a crucial role as a first line of defense against viral infections and tumor development. Iron is an essential nutrient for immune cells, but it can also pose biochemical risks such as the production of reactive oxygen species. The importance of iron for the NK cell function has gained increasing recognition.
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