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In a genome-wide association study (GWAS) meta-analysis of 688,808 individuals with major depression (MD) and 4,364,225 controls from 29 countries across diverse and admixed ancestries, we identify 697 associations at 635 loci, 293 of which are novel. Using fine-mapping and functional tools, we find 308 high-confidence gene associations and enrichment of postsynaptic density and receptor clustering. A neural cell-type enrichment analysis utilizing single-cell data implicates excitatory, inhibitory, and medium spiny neurons and the involvement of amygdala neurons in both mouse and human single-cell analyses.
View Article and Find Full Text PDFEnvironmental justice mapping tools in the United States: A review of national and state tools.
Sci Total Environ
January 2025
Colorado School of Public Health, Colorado State University, Fort Collins, CO, USA; Department of Environmental and Radiological Health Sciences, Colorado State University, Fort Collins, CO, USA. Electronic address:
Environmental justice (EJ) mapping tools are geographic information system (GIS)-based digital maps that integrate environmental, socioeconomic, health, and demographic data to identify areas experiencing environmental injustices. These tools are increasingly used to guide investments toward disadvantaged communities. This review examines 25 EJ tools, describing their functionalities, coverage, and indicator types, ranging from biological susceptibilities to socioeconomic and environmental factors.
View Article and Find Full Text PDFSediment flow connectivity index data for the Apulia region (Italy): An open-source geodatabase and the innovative CONNECTOSED WebGIS platform.
Data Brief
February 2025
Department of Earth and Geoenvironmental Sciences, University of Bari, 70125 Bari, Italy.
An open-source geodatabase and its associate WebGIS platform (CONNECTOSED) were developed to collect and utilize data for the Sediment Flow Connectivity Index (SfCI) for the Apulia region of southern Italy. Maps depicting sediment mobility and connectivity across the hydrographic basins of the Apulia region were generated and stored in the geodatabase. This geodatabase is organized into folders containing data in TIFF, shapefile, Jpeg and Pdf formats, including input variables (digital elevation model, land cover map, rainfall map, and soil units dataset for each hydrographic basin), classification graphs (ranking of variable values), dimensionless index maps (slope, ruggedness, rainfall, land cover, and soil stability) and key products (maps of sediment mobility, SfCI, and applied SfCI).
View Article and Find Full Text PDFIdentifying internal and external shoulder rotation using a kirigami-based shoulder patch.
Wearable Technol
December 2024
College of Engineering, University of Michigan, Ann Arbor, MI, USA.
Internal and external rotation of the shoulder is often challenging to quantify in the clinic. Existing technologies, such as motion capture, can be expensive or require significant time to setup, collect data, and process and analyze the data. Other methods may rely on surveys or analog tools, which are subject to interpretation.
View Article and Find Full Text PDFBibliometric analysis of laryngeal cancer treatment literature (2003-2023).
Heliyon
January 2025
Department of Otolaryngology Head and Neck Surgery, the Second People's Hospital of Shenzhen, the First Affiliated Hospital of Shenzhen University, Shenzhen, Guangdong Province, 518035, China.
Background: Despite advancements in medical science, the 5-year survival rate for laryngeal squamous cell carcinoma remains low, posing significant challenges in clinical management. This study explores the evolution of key topics and trends in laryngeal cancer research. Bibliometric and knowledge graph analysis are utilized to assess contributions in treating this carcinoma and to forecast emerging research hotspots that may enhance future clinical outcomes.
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