AI Article Synopsis
- The study focuses on the clinical challenges of diagnosing Zika virus infections, especially during overlapping epidemics with Dengue, due to similarities in symptoms.
- Conducted at "Joaquín Albarrán" Hospital in Cuba from June to October 2017, the study involved 1541 patients with suspected Zika, confirming infection in 279 through PCR testing.
- Key findings revealed common symptoms like rash and arthralgia, with Zika patients showing more arthralgia, asthenia, and diarrhea; however, the symptoms alone were insufficient for clear clinical diagnosis.
Article Abstract
Background: The clinical characteristics of the most frequent arbovirosis (Dengue, Zika, Chikungunya) are very similar, which is a diagnostic challenge for clinicians.
Objective: To identify the presence of clinical characteristics related to Zika virus infection confirmed by the laboratory in patients during an epidemic of co-infection with Zika and Dengue viruses.
Method: Cross-sectional descriptive study of patients with clinical - epidemiological suspicion of Zika virus infection, who were admitted in the Hospital "Joaquín Albarrán" (La Habana, Cuba), during June 1 to October 31 of 2017. Demographic and symptoms and signs were recorded. By PCR for Zika virus (in blood or urine) the disease was confirmed.
Results: 1541 patients were studied. The most frequent symptoms and signs were rash (93.8%), pruritus (77.9%), arthralgia (60.0%), headache (50.8%), myalgia (46.1%), fever (34.7%), asthenia (31.7%), and conjunctivitis (27.9%). Zika virus infection was confirmed in 279 patients (18.1%). Greater frequency of arthralgia, asthenia, and diarrhea was demonstrated in Zika confirmed patients.
Conclusion: Minor clinical relevance was observed in the symptoms or signs of arboviral disease to support the clinical diagnosis of Zika virus infections by clinician during a Zika-Dengue epidemic. The assessment of the temporality of the onset of Zika and Dengue symptoms of these infections is recommended to assist clinicians in the differential diagnosis.
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| http://dx.doi.org/10.1016/j.jiph.2019.07.006 | DOI Listing |
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