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Can Intrapleural Tissue Plasminogen Activator and Deoxyribonuclease Be Used to Treat Persistent Hemothorax After Robotic Lobectomy?
Cureus
November 2024
Cardiothoracic Surgery, Northeast Georgia Medical Center Gainesville, Gainesville, USA.
Hemothorax is a serious complication following thoracic surgery, often resulting from vessel injury or rib fractures, and is typically managed with chest tube drainage. Persistent or loculated hemothorax, referred to as retained hemothorax, may require more invasive interventions, such as thoracotomy. Although the intrapleural administration of tissue plasminogen activator (tPA) and deoxyribonuclease (DNase) has shown promise in managing pleural infections, its use for hemothorax remains controversial due to bleeding risks.
View Article and Find Full Text PDFAssociation between serum calcium and in-hospital mortality in intensive care unit patients with cerebral infarction: a cohort study.
Front Neurol
October 2024
Neurology Department, Affiliated Hospital of Guizhou Medical University, Guiyang, Guizhou, China.
Background: The relationship between serum calcium levels and the prognosis of cerebral infarction remains controversial.
Purpose: This study aims to investigate the correlation between serum calcium levels and in-hospital mortality in critically ill patients with ischemic stroke admitted to the intensive care unit (ICU).
Methods: A retrospective cohort study was conducted using data from the MIMIC-IV database.
The role of intravenous thrombolysis before mechanical Thrombectomy: A subgroup analysis of the RESILIENT trial.
J Neurol Sci
February 2024
Hospital de Clínicas de Porto Alegre, Porto Alegre, Brazil.
Background: Randomized trials have recently evaluated the non-inferiority of direct thrombectomy versus intravenous thrombolysis (IVT) followed by endovascular therapy in anterior circulation large vessel occlusion (LVO) stroke in patients eligible for IVT within 4.5 h from stroke onset with controversial results. We aimed to assess the effect of IVT on the clinical outcome of mechanical thrombectomy (MT) in the RESILIENT trial.
View Article and Find Full Text PDFThe effect of occlusion location and technique in mechanical thrombectomy for minor stroke.
Interv Neuroradiol
August 2023
Department of Neurological Surgery, University of Miami, Miami, FL, USA.
Introduction: Endovascular mechanical thrombectomy (MT) is an established treatment for large vessel occlusion strokes with a National Institutes of Health Stroke Scale (NIHSS) score of 6 or higher. Data pertaining to minor strokes, medium, or distal vessel occlusions, and most effective MT technique is limited and controversial.
Methods: A multicenter retrospective study of all patients treated with MT presenting with NIHSS score of 5 or less at 29 comprehensive stroke centers.
Syphilis vaccine: challenges, controversies and opportunities.
Front Immunol
April 2023
IrsiCaixa AIDS Research Institute, Badalona, Spain.
Syphilis is a sexually or vertically (mother to fetus) transmitted disease caused by the infection of subspecie (TPA). The incidence of syphilis has increased over the past years despite the fact that this bacterium is an obligate human pathogen, the infection route is well known, and the disease can be successfully treated with penicillin. As complementary measures to preventive campaigns and early treatment of infected individuals, development of a syphilis vaccine may be crucial for controlling disease spread and/or severity, particularly in countries where the effectiveness of the aforementioned measures is limited.
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