AI Article Synopsis
- - NMR spectroscopy is a crucial technique for identifying and analyzing the structure of small molecules, valued for its reliability and quantitative capabilities in various fields like chemical synthesis and metabolomics.
- - A major drawback of traditional NMR is the slow recovery of nuclear spin alignment, leading to wasted experimental time, especially in quantitative NMR where lengthy waiting periods are required.
- - The introduction of paramagnetic gadolinium chelate can significantly improve efficiency and reduce waiting times, allowing for faster and cost-effective high-throughput mixture analysis.
Article Abstract
NMR spectroscopy is an indispensable technique for the determination of the chemical identity and structure of small molecules. The method is especially recognized for its robustness and intrinsically quantitative nature, and has manifested itself as a key analytical platform for diverse fields of application, ranging from chemical synthesis to metabolomics. Unfortunately, the slow recovery of nuclear spin polarization by spin-lattice (T ) relaxation causes most experimental time to be lost on idle waiting. Furthermore, truly quantitative NMR (qNMR) spectroscopy requires waiting times of 5-times the longest T in the sample, making qNMR spectroscopy slow and inefficient. We demonstrate here that co-solute paramagnetic relaxation can mitigate these two problems simultaneously. The addition of a small amount of paramagnetic gadolinium chelate, available in the form of commercial contrast-agent solutions, enables cheap, quantitative, and efficient high-throughput mixture analysis.
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| http://dx.doi.org/10.1002/anie.201908006 | DOI Listing |
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