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| http://dx.doi.org/10.1097/DSS.0000000000002090 | DOI Listing |
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Managing strategies of chemotherapy and radiotherapy-induced oral mucositis.
Cancer Treat Rev
January 2025
State Key Laboratory of Oral Diseases, National Clinical Research Center for Oral Diseases, Chinese Academy of Medical Sciences Research Unit of Oral Carcinogenesis and Management, West China Hospital of Stomatology, Sichuan University, Chengdu, Sichuan 610041, China. Electronic address:
Radiotherapy and chemotherapy are widely employed as primary non-surgical cancer treatments; however, their non-selective cytotoxicity often leads to adverse events such as oral mucositis (OM), particularly in head and neck cancer therapies. International guidelines provide recommendations for managing chemoradiotherapy-induced OM in various clinical contexts. Subsequently, emerging researches have introduced evidence supporting novel approaches or existing regimens for OM prevention and treatment.
View Article and Find Full Text PDFLong-Term Pentoxifylline Therapy Is Associated with a Reduced Risk of Atherosclerotic Cardiovascular Disease by Inhibiting Oxidative Stress and Cell Apoptosis in Diabetic Kidney Disease Patients.
Antioxidants (Basel)
November 2024
Graduate Institute of Biomedical Sciences, China Medical University, 91, Hsueh-Shih Rd., Taichung 40402, Taiwan.
There is limited understanding of the optimal duration and dosage of pentoxifylline (PTX) therapy required to achieve significant reductions in atherosclerotic cardiovascular disease (ASCVD) risk, particularly in patients with diabetic kidney disease (DKD). This study aimed to evaluate the impact of long-term PTX therapy on the risk of ASCVD in patients with DKD who do not have pre-existing cardiovascular disease, while also exploring potential vascular protective mechanisms. This retrospective cohort study included data from Taiwan's Ministry of Health and Welfare's Health and Welfare Data Science Center.
View Article and Find Full Text PDFA systematic review and meta-analysis assessing the impact of pentoxifylline on the healing and recurrence of venous leg ulcers.
Phlebology
December 2024
Section of Vascular Surgery, Department of Surgery and Cancer, Imperial College London, London, UK.
Introduction: Venous leg ulcers (VLU) are the most severe manifestation of venous insufficiency and carry a poor prognosis because of delayed healing and recurrent ulceration. Pentoxifylline (PTX) is an example of a vasoactive medication that can be used alongside compression therapy to help improve ulcer healing rates. A previous review highlighted improved healing of VLU with PTX, although no analysis was made for complete ulcer healing and recurrence following treatment.
View Article and Find Full Text PDFRifaximin treatment in patients with severe alcoholic hepatitis: A multicenter, randomized controlled, open-label, pilot trial.
Ann Hepatol
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Department of Internal Medicine, Bucheon Soonchunhyang University Hospital, Soonchunhyang University College of Medicine, Bucheon, South Korea.
Introduction And Objectives: The short-term mortality of severe alcoholic hepatitis (SAH) is high, but there are no effective treatments to improve short-term mortality other than corticosteroids. This study investigated the effects of adding rifaximin to standard treatment in patients with SAH.
Material And Methods: In this randomized controlled open-label trial, patients with SAH (Maddrey's discriminant function≥32) were randomized to the rifaximin or control group.
Frostbite on Denali: a case series and review of treatment options.
J Wound Care
December 2024
MedStar Georgetown University Hospital, Washington, DC, US.
Article Synopsis
- Frostbite is a serious risk in mountaineering, especially in cold climates, leading to significant injuries like those seen in three climbers on Denali in 2021.
- All affected climbers, healthy men in their 30s to 60s, suffered frostbite primarily on their fingers, with one requiring medical evacuation due to severity.
- Key prevention strategies and awareness of frostbite risks are crucial for mountaineers, especially considering factors like altitude, cold exposure, and potential psychological effects from the COVID-19 pandemic.
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