AI Article Synopsis
- Hypidone hydrochloride (YL-0919) is a new drug combining features of selective serotonin reuptake inhibitors and serotonin receptor agonists aimed at treating major depressive disorder.
- A highly sensitive ultra HPLC-MS/MS method was created to measure YL-0919 levels in plasma samples, which is essential for understanding its pharmacokinetics.
- This validated method was applied successfully in a study with healthy Chinese participants to analyze the drug's pharmacokinetic profiles for the first time.
Article Abstract
Hypidone hydrochloride (YL-0919) was a novel combined selective serotonin reuptake inhibitor and 5-hydroxytryptamine receptor agonist for treatment of major depressive disorder. Quantitation of YL-0919 in plasma samples was critical for evaluation of its pharmacokinetics in clinical studies. An ultra HPLC-MS/MS method has been developed and validated. Plasma samples were extracted by SPE method and then chromatographed on an Acquity BEH C column. Detection was performed on an API-5500 tandem mass spectrometer using positive ESI. A sensitive and robust method was developed and validated for quantitative analysis of YL-0919 in human plasma samples for the first time. And this novel method was successfully applied to investigate pharmacokinetic profiles of YL-0919 in Chinese healthy subjects.
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| http://dx.doi.org/10.4155/bio-2019-0111 | DOI Listing |
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