AI Article Synopsis
- L. (common walnut) has been traditionally recognized for various medicinal benefits, including antioxidant and antimicrobial properties.
- The study evaluated the antibacterial and anti-biofilm effects of walnut pellicle extract on specific bacteria, using methods like thin layer chromatography and UPLC-Ms/Ms for chemical analysis.
- The extract demonstrated notable antibacterial activity at varying concentrations and effectively reduced biofilm formation, suggesting that its benefits may be linked to its high flavonoid and phenolic content, warranting further research.
Article Abstract
L. (common walnut) is a deciduous tree belonging to Juglandaceae family. Since ancient time, walnut was widely used in traditional medicine for its antioxidant, antidiabetic, antimicrobial, anti-inflammatory, anti-atherogenic and liver-protective effects. In this work, the antibacterial and anti-biofilm activities of walnuts pellicle extract against coagulase-negative staphylococci were evaluated. Qualitative chemical analysis was performed by the thin layer chromatography. UPLC-Ms/Ms was used to identify the chemical composition of extract. The total flavonoid and phenolic contents were determined by the Aluminium chloride and Folin-Ciocalteu methods, respectively. The extract showed antibacterial activity with MIC ranging from 3.60 to 461.75 µg/ml and MBC ranging from 461.75 to >461.75 µg/ml. Furthermore, it significantly reduced biofilm biomass and cell viability in a dose-dependent manner. Biological activities of extract may be due to its high flavonoid and phenolic contents. The obtained results are promising and they deserve further scientific investigations.
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| http://dx.doi.org/10.1080/14786419.2019.1650352 | DOI Listing |
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