A 70-year-old end-stage renal disease patient was admitted for refractory hypoglycemia secondary to drug-drug interaction between clarithromycin and glipizide. We discussed the mechanism of antimicrobial and sulfonylurea interactions as well as the importance of understanding these interactions in the primary care setting to reduce medication-related hospitalizations.
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Clarithromycin and Glipizide Drug-drug Interaction Leading to Refractory Hypoglycemia.
Cureus
June 2019
Internal Medicine, Singapore General Hospital, Singapore, SGP.
A 70-year-old end-stage renal disease patient was admitted for refractory hypoglycemia secondary to drug-drug interaction between clarithromycin and glipizide. We discussed the mechanism of antimicrobial and sulfonylurea interactions as well as the importance of understanding these interactions in the primary care setting to reduce medication-related hospitalizations.
View Article and Find Full Text PDFHypoglycemia after antimicrobial drug prescription for older patients using sulfonylureas.
JAMA Intern Med
October 2014
Sealy Center on Aging, University of Texas Medical Branch, Galveston2Department of Internal Medicine, University of Texas Medical Branch, Galveston3Department of Preventive Medicine, University of Texas Medical Branch, Galveston4Department of Community He.
Importance: Certain antimicrobial drugs interact with sulfonylureas to increase the risk of hypoglycemia.
Objective: To determine the risk of hypoglycemia and associated costs in older patients prescribed glipizide or glyburide who fill a prescription for an antimicrobial drug.
Design, Setting, And Participants: This was a retrospective cohort study of Texas Medicare claims from 2006 to 2009 for patients 66 years or older who were prescribed glipizide or glyburide and who also filled a prescription for 1 of the 16 antimicrobials most commonly prescribed for this population.
Anti-infectives and the risk of severe hypoglycemia in users of glipizide or glyburide.
Clin Pharmacol Ther
August 2010
Department of Biostatistics and Epidemiology, University of Pennsylvania School of Medicine, Center for Clinical Epidemiology and Biostatistics, Philadelphia, Pennsylvania, USA.
The objective of this study was to evaluate whether orally administered anti-infectives increase the risk of severe hypoglycemia in users of glipizide or glyburide. We performed two case-control studies and two case-crossover studies using US Medicaid data. All the anti-infectives examined were associated with an elevated risk of severe hypoglycemia.
View Article and Find Full Text PDFRepaglinide : a pharmacoeconomic review of its use in type 2 diabetes mellitus.
Pharmacoeconomics
June 2004
Adis International Limited, Auckland, New Zealand.
Repaglinide (Prandin), NovoNorm, GlucoNorm, an oral insulin secretagogue, was the first meglitinide analogue to become available for use in patients with type 2 diabetes mellitus. The drug lowers postprandial glucose excursions by targeting early-phase insulin release, an effect thought to be important in reducing long-term cardiovascular complications of diabetes. Repaglinide provided similar overall glycaemic control to that achieved with glibenclamide (glyburide), as assessed by glycosylated haemoglobin (HbA(1c)) and fasting blood glucose levels, and was generally well tolerated in well designed clinical trials.
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