Two New Flavonoids from the Nuts of .

Molecules

Institute of Traditional Chinese Medicine & Natural Products, Guangdong Provincial Engineering Research Center for Modernazation of TCM, College of Pharmacy, Jinan University, Guangzhou 510632, China.

Published: August 2019

Two new flavonoids, calquiquelignan M (), calquiquelignan N (), along with nine known compounds (-), were isolated from the nuts of (Palmae). The new structures, including absolute configurations, were established by a combination of spectroscopic data and electronic circular dichroism (ECD) calculation. The known compounds were identified by comparing their spectroscopic data with reported in the literature. The flavonoids compounds (-) were evaluated for their cytotoxicity activities against three human cancer cell lines. Compounds and exhibited a moderate cytotoxic activity against HepG2 cell lines with IC values of 49.8 and 53.6 μM, respectively.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6721780PMC
http://dx.doi.org/10.3390/molecules24162862DOI Listing

Publication Analysis

Top Keywords

spectroscopic data
8
cell lines
8
flavonoids nuts
4
nuts flavonoids
4
flavonoids calquiquelignan
4
calquiquelignan calquiquelignan
4
compounds
4
calquiquelignan compounds
4
compounds isolated
4
isolated nuts
4

Similar Publications

The extract of the stems of R. Br. yielded three new terpenes () including two diterpenes and one triterpene, named euryachins C-E, as well as three known diterpenes ().

View Article and Find Full Text PDF

The topic of data storage, traceability, and data use and reuse in the years following experiments is becoming an important topic in Europe and across the world. Many scientific communities are striving to create open data by the FAIR principles. This is a requirement from the European Commission for EU-funded projects and experiments at EU-funded research infrastructures (RIs) and from many national funding agencies.

View Article and Find Full Text PDF

We report the synthesis and characterization of an iron(III)-hydroperoxo complex generated from salicylate-assisted dioxygen activation by a cation-liganded iron(II) complex. Spectroscopic and theoretical data revealed stabilization of the end-on hydroperoxo ligand, and mechanistic insights, including a "V-shaped" Hammett plot, were confirmed by conducting oxygen atom transfer and proton-coupled electron transfer reactions.

View Article and Find Full Text PDF

Antibacterial and Cytotoxic Methylthioether-Containing Cytochalasins from AS-506, an Endozoic Fungus Associated with Deep-Sea Sponge of Magellan Seamounts.

J Agric Food Chem

January 2025

CAS and Shandong Province Key Laboratory of Experimental Marine Biology, Institute of Oceanology, Chinese Academy of Sciences, Nanhai Road 7, Qingdao 266071, China.

Ten cytochalasin derivatives, including six new methylthioether-containing chaetoglobosins (thiochaetoglobosins A-F, ), a new related congener (18-nor-prochaetoglobosin II, ), and three known unsulfured counterparts (), were isolated and identified from AS-506, an endozoic fungus isolated from a deep-sea sponge, which was collected from Magellan Seamounts in the Western Pacific Ocean. Their structures were determined by extensive interpretation of the spectroscopic and X-ray crystallographic data, as well as by ECD calculations. Structurally, thiochaetoglobosins A-F () represent the first examples of chaetoglobosin derivatives containing a methylthioether group in the molecules, while 18-nor-prochaetoglobosin II () is the first 18-nor-chaetoglobosin derivative.

View Article and Find Full Text PDF

Hericinosides A-M, Cyathane Diterpene Glycosides with α-Glucosidase Inhibitory Activity from the Medicinal Fungus .

J Agric Food Chem

January 2025

Anhui Province Key Laboratory of Bioactive Natural Products, School of Pharmacy, Anhui University of Chinese Medicine, Hefei 230000, China.

Thirteen new cyathane diterpene glycosides, hericinosides A-M (-), and six known analogs, were isolated from the rice media fermentation of the medicinal fungus . The sugar parts of and were highly modified, forming a unique 5/6/7/5/5/5 ring new skeleton system. All structures were elucidated based on spectroscopic data, and their relative configurations were determined according to the ROESY analysis.

View Article and Find Full Text PDF

Want AI Summaries of new PubMed Abstracts delivered to your In-box?

Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!