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A preliminary study of further attempt at the development, testing and application of an auxiliary equipment for electronic colonoscopy.
Sci Rep
December 2024
Endoscopic Center, The Second Affiliated Hospital of Harbin Medical University, Harbin, 150000, China.
Colonoscopy is a valuable tool for colorectal cancer screening and health checkups, with increasing utilization annually. Assisted entry is a standard procedure during electronic colonoscopy. In China, most clinically assisted colonoscopy procedures involve a nurse directly applying abdominal pressure to the patient's abdomen.
View Article and Find Full Text PDFPortable emissions toxicity system: Evaluating the toxicity of emissions or polluted air by exposure of cell cultures at air-liquid interface in a compact field-deployable setup.
Sci Total Environ
December 2024
Institute of Experimental Medicine of the Czech Academy of Sciences, Videnska 1084, Prague 4, Czech Republic.
Exposure of cell cultures at air-liquid interface (ALI), mimicking i.e. human lung surface, is believed to be one of the most realistic means to model toxicity of complex mixtures of pollutants on human health.
View Article and Find Full Text PDFKRBP72 facilitates ATPase-dependent editing progression through a structural roadblock in mitochondrial A6 mRNA.
Nucleic Acids Res
December 2024
Department of Microbiology and Immunology, University at Buffalo Jacobs School of Medicine and Biomedical Sciences, 955 Main Street, Buffalo, NY 14203, USA.
Uridine insertion/deletion editing of mitochondrial messenger RNAs (mRNAs) in kinetoplastids entails the coordinated action of three complexes. RNA Editing Catalytic Complexes (RECCs) catalyze the enzymatic reactions, while the RNA Editing Substrate Binding Complex (RESC) and RNA Editing Helicase 2 Complex (REH2C) coordinate interactions between RECCs, mRNAs and hundreds of guide RNAs that direct edited sequences. Additionally, numerous auxiliary factors are required for productive editing of specific mRNAs.
View Article and Find Full Text PDFExpression and Purification of ADAMTSL5 in E. coli and Validation of Activity in Psoriasis Serum.
Immun Inflamm Dis
December 2024
Department of Laboratory Medicine, The People's Hospital of Guangxi Zhuang Autonomous Region,The Guangxi Key Laboratory of intelligent precision medicine, Nanning, Guangxi Zhuang Autonomous Region, China.
Purpose: A disintegrin and metalloprotease domain containing thrombospondin type 1 motif-like 5 (ADAMTSL5), a protein linked to psoriasis, was obtained by prokaryotic expression and purification for potential utilization as a new auxiliary diagnostic marker for psoriasis. It was subsequently applied in psoriasis research.
Experimental Design: The designed ADAMTSL5 gene was inserted into the pET-30a (+) vector and expressed in the BL21 (DE3) strain as a fusion protein.
DRBD18 acts as a transcript-specific RNA editing auxiliary factor in Trypanosoma brucei.
RNA
December 2024
Department of Microbiology and Immunology, Jacobs School of Medicine and Biomedical Sciences, University at Buffalo, Buffalo, New York, 14203, USA
Uridine insertion/deletion (U-indel) RNA editing of mitochondrial transcripts is a posttranscriptional modification in kinetoplastid organisms, resulting in the generation of mature mRNAs from cryptic precursors. This RNA editing process involves a multi-protein complex holoenzyme and multiple accessory factors. Recent investigations have highlighted the pivotal involvement of accessory RNA binding proteins (RBPs) in modulating RNA editing in T.
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