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http://dx.doi.org/10.21037/atm.2019.05.57 | DOI Listing |
Euroasian J Hepatogastroenterol
December 2024
Department of Gastroenterology and Metabology, Ehime University Graduate School of Medicine, Ehime, Japan.
Objectives: To predict and characterize the three-dimensional (3D) structure of protein arginine methyltransferase 2 (PRMT2) using homology modeling, besides, the identification of potent inhibitors for enhanced comprehension of the biological function of this protein arginine methyltransferase (PRMT) family protein in carcinogenesis.
Materials And Methods: An method was employed to predict and characterize the three-dimensional structure. The bulk of PRMTs in the PDB shares just a structurally conserved catalytic core domain.
Actas Esp Psiquiatr
January 2025
Department of Psychology, University of Jaén, 23071 Jaén, Spain.
This editorial explores the dynamic psychiatric research field by focusing on interdisciplinary approaches to understand the complexity of mental disorders by placing particular emphasis on schizophrenia. It highlights the need to integrate findings from diverse scientific disciplines, such as neuroscience, computational modeling and genomics, to unravel the multifaceted nature of these conditions. The potential of interdisciplinary research to transform our knowledge and the treatment of psychiatric disorders is underscored by moving beyond traditional models and developing more nuanced frameworks to more effectively address these complexities.
View Article and Find Full Text PDFJ Oral Facial Pain Headache
December 2024
Department of Experimental Dentistry, Wroclaw Medical University, 50-425 Wroclaw, Poland.
Temporomandibular disorders (TMD) comprise a group of conditions affecting the masticatory muscles, the temporomandibular joints and associated structures, often manifesting as orofacial pain and functional limitations of the mandible. Central sensitization (CS) is gaining increasing attention in research focused on pain syndromes and somatization, playing a significant role in the pain experience. This study investigates the prevalence of CS and somatization among TMD patients, analyzing their relationships with TMD diagnoses and the intensity of chronic masticatory muscle pain (MMP).
View Article and Find Full Text PDFCochrane Database Syst Rev
January 2025
Nuffield Department of Primary Care Health Sciences, University of Oxford, Oxford, UK.
Background: Financial incentives (money, vouchers, or self-deposits) can be used to positively reinforce smoking cessation. They may be used as one-off rewards, or in various schedules to reward steps towards sustained smoking abstinence (known as contingency management). They have been used in workplaces, clinics, hospitals, and community settings, and to target particular populations.
View Article and Find Full Text PDFCNS Drugs
January 2025
New York State Psychiatric Institute, 1051 Riverside Drive, New York, NY, 10032, USA.
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