A rhodium-catalyzed highly regio- and enantioselective hydroalkynylation, generating -hydrobenzofuranone-tethered enynes has been developed. The reaction proceeds with a selective head-to-head insertion and symmetry breaking Michael addition cascade. One product was produced from tens of possible isomers through precise control of chemo-, regio-, and stereoselectivities using a single rhodium catalyst. Notable features of this method include 100% atom-economy, mild reaction conditions and a very broad substrate scope.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6657412 | PMC |
| http://dx.doi.org/10.1039/c9sc02341k | DOI Listing |
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