AI Article Synopsis
- The study investigates the association of YKL-40 and IMA protein levels in women with hyperemesis gravidarum (HG) as potential markers for inflammation and oxidative stress.
- The research included 35 patients with HG and 35 healthy pregnant women, with assessments on various health parameters, revealing no significant differences in demographic or IMA levels between the groups.
- Although YKL-40 levels were higher in HG patients, the difference was also not statistically significant, indicating a need for larger studies to confirm the potential relationship between these markers and HG.
Article Abstract
Introduction: The etiopathogenesis of HG is still unclear.
Aim: The aim of this study was to investigate the levels of YKL-40 protein as an inflammatory marker and evaluate the levels of IMA as an oxidative marker in hyperemesis gravidarum women.
Materials And Methods: Totally 35 patients with hyperemesis gravidarum and 35 healthy pregnants were included in the study. Singleton pregnancies between 6+0 week and 13+6 weeks of gestation, with normal fetal anatomy were included in the study. Complete blood count, complete urine analyze, biochemical tests and thyroid function tests were done.
Results: There was no significant difference between groups for demographical features (age, gravidity, gestational age, body mass index). Also, there was no statistically significant difference between groups for IMA levels (p>0.05). The median level of YKL-40 was higher in pregnants with hyperemesis gravidarum than normal pregnants but the difference was not statistically significance (p>0.05).
Conclusion: Further comprehensive studies with more number of patients are needed to show the efficacy of YKL-40 and IMA levels for predicting hyperemesis gravidarum and even monitoring of the treatment.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6643323 | PMC |
| http://dx.doi.org/10.5455/medarh.2019.73.97-100 | DOI Listing |
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