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Bioresorbable photonic devices for the spectroscopic characterization of physiological status and neural activity. | LitMetric

AI Article Synopsis

  • The text discusses the potential of real-time monitoring of internal body processes to improve drug delivery, surgical procedures, and recovery management.* -
  • Current monitoring techniques have limitations, such as requiring surgery or not providing continuous data, while the proposed solution involves injectable photonic devices that naturally dissolve in the body.* -
  • These devices can continuously monitor important physiological factors like brain temperature and oxygen levels in live subjects, which could advance research in disease, neuroscience, and recovery after illness or injury.*

Article Abstract

Capabilities in real-time monitoring of internal physiological processes could inform pharmacological drug-delivery schedules, surgical intervention procedures and the management of recovery and rehabilitation. Current methods rely on external imaging techniques or implantable sensors, without the ability to provide continuous information over clinically relevant timescales, and/or with requirements in surgical procedures with associated costs and risks. Here, we describe injectable classes of photonic devices, made entirely of materials that naturally resorb and undergo clearance from the body after a controlled operational lifetime, for the spectroscopic characterization of targeted tissues and biofluids. As an example application, we show that the devices can be used for the continuous monitoring of cerebral temperature, oxygenation and neural activity in freely moving mice. These types of devices should prove useful in fundamental studies of disease pathology, in neuroscience research, in surgical procedures and in monitoring of recovery from injury or illness.

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Source
http://dx.doi.org/10.1038/s41551-019-0435-yDOI Listing

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