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Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation. | LitMetric

Morphogenesis of extra-embryonic tissues directs the remodelling of the mouse embryo at implantation.

Nat Commun

Mammalian Embryo and Stem Cell Group, University of Cambridge, Department of Physiology, Development and Neuroscience, Downing Street, Cambridge, CB2 3DY, UK.

Published: August 2019

AI Article Synopsis

  • Mammalian embryos undergo significant shape changes during implantation, but the cellular and molecular processes behind this transformation are not fully understood.
  • Research indicates that the interaction between the embryonic epiblast and the extra-embryonic trophectoderm is crucial for these changes, specifically through FGF signaling from the epiblast that influences the trophectoderm's development.
  • These interactions result in the formation of a tissue boundary which is vital for the trophectoderm's growth into a layered structure, ultimately reshaping the embryo for successful implantation.

Article Abstract

Mammalian embryos change shape dramatically upon implantation. The cellular and molecular mechanism underlying this transition are largely unknown. Here, we show that this transition is directed by cross talk between the embryonic epiblast and the first extra-embryonic tissue, the trophectoderm. Specifically, we show via visualisation of a Cdx2-GFP reporter line and pharmacologically mediated loss and gain of function experiments that the epiblast provides FGF signal that results in differential fate acquisition in the multipotent trophectoderm leading to the formation of a tissue boundary within this tissue. The trophectoderm boundary becomes essential for expansion of the tissue into a multi-layered epithelium. Folding of this multi-layered trophectoderm induces spreading of the second extra-embryonic tissue, the primitive endoderm. Together, these events remodel the pre-implantation embryo into its post-implantation cylindrical shape. Our findings uncover how communication between embryonic and extra-embryonic tissues provides positional cues to drive shape changes in mammalian development during implantation.

Download full-text PDF

Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6686005PMC
http://dx.doi.org/10.1038/s41467-019-11482-5DOI Listing

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