Peach ( (L.) Batsch) is a popular fruit consumed by people worldwide, owing to its pleasant flavor and high mineral nutrient content. A few plants from the genus , such as , , and have shown vasorelaxant and vasodilatory effects, to date, no study has investigated the vasorelaxation effects of the branch extract (PPE). The vasorelaxant effect of PPE was endothelium-dependent, and it was related to the NO-sGC-cGMP, vascular prostacyclin, and muscarinic receptor transduction pathway. K channels, such as the BK, K, and K channels, were partially associated with PPE-induced vasorelaxation. PPE was effective in relaxing serotonin (5-HT)- or angiotensin II-induced contraction; furthermore, PPE attenuated Ca-induced vasoconstriction by IP receptors in the SR membrane, but its vasorelaxant effect was not associated with the influx of extracellular Ca via receptor-operative Ca channels or voltage-dependent Ca channels. Recognizing the rising use of functional foods for hypertension treatment, our findings imply that PPE may be a natural antihypertensive agent.
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| http://dx.doi.org/10.3390/nu11081816 | DOI Listing |
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