AI Article Synopsis
- Sundaravinayagam et al. (2019) discovered that 53BP1 plays a significant role in class switch recombination in B cells, which is important for producing different antibody classes.
- This study moves beyond the previously known function of 53BP1, which primarily focused on limiting end resection during DNA repair.
- The research highlights the broader implications of 53BP1's involvement in immune responses and B cell function.
Article Abstract
Sundaravinayagam et al. (2019) uncovered a critical role of 53BP1 in class switch recombination in B cells beyond its role in limiting end resection.
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| http://dx.doi.org/10.1016/j.celrep.2019.07.076 | DOI Listing |
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