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Endotracheal tube mucus as a source of airway mucus for rheological study. | LitMetric

AI Article Synopsis

  • - MOLDs, including cystic fibrosis and chronic obstructive pulmonary disease, are global health issues caused by hyperconcentrated airway mucus that hinders clearance.
  • - Research on MOLDs necessitates healthy mucus samples; endotracheal tube (ETT) mucus is a promising alternative due to its in vivo production advantages over traditional samples like sputum.
  • - The study characterized the ionic and biochemical properties of ETT mucus, showing its rheologic properties align with those of individual ETT and human bronchial epithelial samples, suggesting its utility in MOLD research.

Article Abstract

Muco-obstructive lung diseases (MOLDs), like cystic fibrosis and chronic obstructive pulmonary disease, affect a spectrum of subjects globally. In MOLDs, the airway mucus becomes hyperconcentrated, increasing osmotic and viscoelastic moduli and impairing mucus clearance. MOLD research requires relevant sources of healthy airway mucus for experimental manipulation and analysis. Mucus collected from endotracheal tubes (ETT) may represent such a source with benefits, e.g., in vivo production, over canonical sample types such as sputum or human bronchial epithelial (HBE) mucus. Ionic and biochemical compositions of ETT mucus from healthy human subjects were characterized and a stock of pooled ETT samples generated. Pooled ETT mucus exhibited concentration-dependent rheologic properties that agreed across spatial scales with reported individual ETT samples and HBE mucus. We suggest that the practical benefits compared with other sample types make ETT mucus potentially useful for MOLD research.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6842913PMC
http://dx.doi.org/10.1152/ajplung.00238.2019DOI Listing

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