Cu(I)-catalyzed intramolecular annulation of -ethynylquinoline-3-carbaldehydes leads to the synthesis of alkoxy/imidazole-substituted 1,3-dihydrofuro[3,4-]quinolines via C-O and C-N bond formation. The scope of the reaction was further extended to -ethynylquinoline-3-carbonitriles for the synthesis of alkoxy-substituted 3-pyrrolo[3,4-]quinolines using alcohols as nucleophiles. These reactions are regioselectively favoring the 5- cyclizations in all the annulation processes.
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| http://dx.doi.org/10.1021/acs.joc.9b00662 | DOI Listing |
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