AI Article Synopsis
- Frailty is characterized by reduced functional reserve, leading to higher morbidity and mortality, and this study investigates the link between IL10 gene polymorphisms and frailty in a Mexican population.
- The research analyzed 984 participants, categorizing them into nonfrail, prefrail, and frail groups, revealing associations between specific IL10 polymorphisms (rs1800896, rs1800871) and increased frailty susceptibility.
- Two risk haplotypes (ACG and CCG) and three protective haplotypes (ACA, ATG, and ATA) were identified, indicating that certain genetic variations in IL10 may influence frailty risk in older adults.
Article Abstract
Frailty is a geriatric syndrome, characterized by a loss in functional reserve with an increase in morbidity and mortality. There are no reports that link the genetic polymorphisms between interleukin 10 (IL10) and frailty; for this reason, our objective was used to analyze the role of the polymorphisms of IL10 (rs1800896, rs1800871) in the susceptibility to frailty in a Mexican population. Our study included 984 participants divided into 368 nonfrail, 309 prefrail, and 307 frail. The models for the polymorphisms rs1800896 and rs1800871 were recessive models in association with frailty (OR = 2.3, CI 95% = 1.6-3.2; OR = 1.53, CI 95% = 1.0-2.6), respectively. Two risk haplotypes were identified: ACG and CCG (p < .0001), and three protective haplotypes were identified: ACA, ATG, and ATA (p < .05). This study evaluated the relationship between IL10 and the three subtypes of this geriatric syndrome (frail, prefrail, and nonfrail). These results support a greater susceptibility to frailty for the minor alleles of rs1800871 and rs1800896. In addition, we found two risk haplotypes supporting the participation of the IL10 in the susceptibility for frailty in the Mexican population.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6732283 | PMC |
| http://dx.doi.org/10.1002/mgg3.918 | DOI Listing |
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