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| http://dx.doi.org/10.1007/s12288-019-01110-z | DOI Listing |
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[Abnormal hemoglobinopathy in Hb Titusville: a case report].
Zhonghua Xue Ye Xue Za Zhi
December 2023
Department of Clinical Laboratory, the Fifth Affiliated Hospital of Sun Yat-sen University, Zhuhai 519000, China.
Background: Normal hemoglobin is a tetrameric structure, consisting of two alpha-globin chains and two nonalpha (beta, gamma, delta) chains. Hemoglobinopathies occur when the presence of gene mutations affect the molecular structure or expression of the globin chains.
Methods: We reported the case of a 9-year-old Chinese girl who presented with abnormal low oxygen saturation values on pulse oximetry and no oximetry results were obtained during blood gas analysis (BGA).
Hemoglobin Titusville [α2 Codon 94 G>A]: A Rare Alpha Globin Chain Variant Causing Low Oxygen Saturation.
Indian J Hematol Blood Transfus
July 2019
Division of Hematogenetics, National Institute of Immunohematology, Mumbai, India.
Oxygenation during general anesthesia and thoracic surgery in a patient with Titusville low-oxygen affinity hemoglobin.
J Appl Physiol (1985)
April 2019
Department of Anesthesia, Critical Care, and Emergency, Fondazione IRCCS Ca'Granda-Ospedale Maggiore Policlinico, Milan , Italy.
The purpose of this case study is to describe the physiological characteristics of a patient with the low-oxygen affinity Titusville hemoglobin variant. A 46-yr-old man with exertional dyspnea was diagnosed with a mediastinal lymphadenopathy of unknown origin and, to obtain definitive diagnosis by biopsy, underwent endobronchial ultrasound-guided transbronchial needle aspirate under sedation and video-assisted thoracoscopy under general anesthesia. High inspired fraction of oxygen ( ) was used to guarantee adequate oxygenation even during the one-lung ventilation needed for thoracoscopy.
View Article and Find Full Text PDFHaemoglobin Titusville: low oxygen saturations but is the patient hypoxaemic?
QJM
December 2018
Department of Haematology, Aberdeen Royal Infirmary, Foresterhill Campus, Aberdeen, UK.
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