AI Article Synopsis
- Esophageal cancer is a major type of cancer that significantly contributes to deaths caused by cancer.
- Both genetic and epigenetic factors, like DNA methylation and histone changes, play crucial roles in how genes are expressed in this disease.
- Recent studies highlight the involvement of noncoding RNAs, especially lncRNAs and miRNAs, in the epigenetic regulation that affects the development and progression of esophageal cancer.
Article Abstract
Esophageal cancer (EC) is a serious digestive malignancy and is a leading cause of cancer-related mortality. Apart from genetic mutations, many epigenetic alterations including DNA methylation and histone modifications associated with chromatin remodeling have been identified in the regulation of gene expression in EC. Recently, noncoding RNAs, and mainly lncRNAs and miRNAs, have been revealed to be involved in the epigenetic regulation of EC. In this review, we focus on describing new insights on epigenetic processes associated with noncoding RNAs, which have been characterized to be responsible for the development and progression of EC.
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| http://dx.doi.org/10.1016/j.biopha.2019.109192 | DOI Listing |
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