Cytotoxic ergosterols from cultures of the basidiomycete Psathyrella candolleana.

Fitoterapia

School of Pharmaceutical Sciences, South-Central University for Nationalities, Wuhan 430074, China; National Demonstration Center for Experimental Ethnopharmacology Education, South-Central University for Nationalities, China. Electronic address:

Published: October 2019

Three newly isolated ergosterols, psathergosterols A-C (1-3), together with two known ones (4 and 5), have been isolated from cultures of the basdiomycete Psathyrella candolleana. Their structures with the absolute configuration were elucidated by means of spectroscopic methods and the single crystal X-ray diffraction. Compounds 2-4 exhibited certain cytotoxicities to five human cancer cell lines (HL-60, SMMC-7721, A-549, MCF-7, SW480).

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http://dx.doi.org/10.1016/j.fitote.2019.104289DOI Listing

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