The surface of a higher order topological insulator comprises a two-dimensional topological insulator (TI) with broken inversion symmetry, whose mass is determined by the microscopic details of the surface such as surface potentials and termination. It hosts a helical mode pinned to selected hinges where the surface gap changes its sign. We study the effect of perturbations that break time reversal and particle conservation on this helical mode, such as a Zeeman field and a proximate superconductor. We find that in contrast to the helical modes of inversion symmetric TIs, which are gapped by these couplings, the helical modes at the hinges can remain gapless and spatially split. When this happens, the Zeeman field splits the helical mode into a chiral mode surrounding the magnetized region, and a superconductor results in a helical Majorana mode surrounding the superconducting region. The combination of the two might lead to the gapping of one of the chiral Majorana modes, and leave a single one-dimensional chiral Majorana mode around the superconducting island. We propose that the different topological states can be measured in electrical transport.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1103/PhysRevLett.123.036802 | DOI Listing |
T cell receptor (TCR) mimics offer a promising platform for tumor-specific targeting of peptide-MHC in cancer immunotherapy. Here, we designed a α-helical TCR mimic (TCRm) specific for the NY-ESO-1 peptide presented by HLA-A 02, achieving high on-target specificity with nanomolar affinity (K = 9.5 nM).
View Article and Find Full Text PDFNat Commun
January 2025
CAS Key Laboratory of Mechanical Behavior and Design of Materials, Department of Modern Mechanics, CAS Center for Excellence in Complex System Mechanics, University of Science and Technology of China, Hefei, Anhui, China.
Control of crack propagation is crucial to make tougher heterogeneous materials. As a crack interacts with material heterogeneities, its front distorts and adopts complex tortuous configurations. While the behavior of smooth cracks with straight fronts in homogeneous materials is well understood, the toughening by rough cracks with tortuous fronts in heterogeneous materials remains unsolved.
View Article and Find Full Text PDFNat Commun
December 2024
Experimental Medicine & Immunotherapeutics, University of Cambridge, Cambridge, UK.
We describe a structural and functional study of the G protein-coupled apelin receptor, which binds two endogenous peptide ligands, apelin and Elabela/Toddler (ELA), to regulate cardiovascular development and function. Characterisation of naturally occurring apelin receptor variants from the UK Genomics England 100,000 Genomes Project, and AlphaFold2 modelling, identifies T89 as important in the ELA binding site, and R168 as forming extensive interactions with the C-termini of both peptides. Base editing to introduce an R/H168 variant into human stem cell-derived cardiomyocytes demonstrates that this residue is critical for receptor binding and function.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
December 2024
Department of Pharmacy, Ludwig-Maximilians-Universität München, Butenandtstr. 5-13, 81377, München, Germany.
Helical aromatic oligoamide foldamers bearing anionic side chains that mimic the overall shape and charge surface distribution of DNA were synthesized. Their interactions with chromosomal protein Sac7d, a non-sequence-selective DNA-binder that kinks DNA, were investigated by Surface Plasmon Resonance (SPR), Isothermal Titration Calorimetry (ITC), Circular Dichroism spectroscopy (CD), melting curve analysis, Atomic Force Microscopy (AFM), and Nuclear Magnetic Resonance (NMR), as well as by single crystal X-ray crystallography. The foldamers were shown to bind to Sac7d better than a DNA duplex of comparable length.
View Article and Find Full Text PDFCrit Rev Biochem Mol Biol
December 2024
The Salk Institute for Biological Studies, La Jolla, California, USA.
This review documents investigations leading to the unprecedented discovery of filamentation as a mode of enzyme regulation in the type II restriction endonuclease SgrAI. Filamentation is defined here as linear or helical polymerization of a single enzyme as occurs for SgrAI, and has now been shown to occur in many other enzyme systems, including conserved metabolic enzymes. In the case of SgrAI, filamentation activates the DNA cleavage rate by up to 1000-fold and also alters the enzyme's DNA sequence specificity.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!