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Blarcamesine for the treatment of Early Alzheimer's Disease: Results from the ANAVEX2-73-AD-004 Phase IIB/III trial.
J Prev Alzheimers Dis
January 2025
Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona, USA. Electronic address:
Background: There are no approved oral disease-modifying treatments for Alzheimer's disease (AD).
Objectives: The objective of this study was to assess efficacy and safety of blarcamesine (ANAVEX®2-73), an orally available small-molecule activator of the sigma-1 receptor (SIGMAR1) in early AD through restoration of cellular homeostasis including autophagy enhancement.
Design: ANAVEX2-73-AD-004 was a randomized, double-blind, placebo-controlled, 48-week Phase IIb/III trial.
Sham treatment? Should it be redefined for its use in manual therapy clinical studies?
J Man Manip Ther
February 2025
Center for Rehabilitation Research, Texas Tech University Health Sciences Center, Lubbock, TX, USA.
Robotic-Assisted Total Knee Arthroplasty: Innovations, Precision, and the Future of Joint Reconstruction.
J Orthop Case Rep
December 2024
Department of Orthopedic, Sancheti Institute for Orthopaedics and Rehabilitation, Pune, Maharashtra, India.
Article Synopsis
- * These systems provide benefits such as improved functional outcomes, reduced revision rates, and quicker recovery, especially in complex surgeries, while offering surgeons consistent results in challenging anatomies.
- * The MISSO Robotic System is positioned as a cost-effective solution for South Asian patients, addressing region-specific anatomical challenges and increasing accessibility in high-demand healthcare settings, which ultimately aims to redefine orthopedic surgical standards.
Pasta: Is It an Unhealthy Refined Food?
J Nutr
December 2024
Department of Clinical Medicine and Surgery, Federico II University, Naples, Italy.
Article Synopsis
- - Pasta has a low glycemic index and is a key component of the Mediterranean diet, providing dietary fiber because it's made from durum wheat semolina, which retains its structural integrity.
- - Although typically classed as a refined carbohydrate and part of "unhealthy plant-based diets", pasta has shown health benefits in various studies, challenging this negative perception.
- - There's a growing call for re-evaluating how we categorize dietary carbohydrates to better reflect their structural complexity and positive health impacts.
Redefining Urban Recreation: A Demand Analysis for Urban Year-Round Green Exercise.
Int J Environ Res Public Health
November 2024
Institute of Sports Science, University of the Bundeswehr Munich, 85579 Neubiberg, Germany.
Urban green exercise offers substantial physical and mental health benefits, especially in urban environments with limited natural access. This study analyzes the demand for urban year-round green exercise under various meteorological conditions. Using a primary empirical research design, data were collected from 408 active participants in Germany through an online survey.
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